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Proceedings of the Society for Experimental Biology and Medicine, Vol 173, 137-139, Copyright © 1983 by Society for Experimental Biology and Medicine

ORIGINAL ARTICLES

Effect of copper or insulin in diabetic copper-deficient rats

M Fields, S Reiser and JC Smith Jr

The effects of copper and insulin on lipogenesis and glucose tolerance were studied using diabetic, copper-deficient rats. Diabetes was induced by intraperitoneal injection of 50 mg streptozotocin/kg body weight to rats fed a sucrose-copper deficient diet for 7 weeks. Five days later the rats were injected intraperitoneally with [14C]glucose with either saline, insulin, copper, or copper plus insulin. The disappearance of serum [14C]glucose at 30, 60, and 120 min postinjection and the incorporation of [14C]glucose into lipid of epididymal fat 2 hr after administration were determined. The combined effect of copper and insulin significantly decreased peak blood glucose at 30 min and increased the incorporation of [14C]glucose into lipid in the epididymal fat pad when compared to either copper or insulin alone. The enhancement of glucose utilization may be due to a formation of a more stable complex which will increase insulin binding and/or decrease its degradation.


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J. T. Saari, P. G. Reeves, W. T. Johnson, and L. K. Johnson
Pinto Beans Are a Source of Highly Bioavailable Copper in Rats
J. Nutr., December 1, 2006; 136(12): 2999 - 3004.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by the Society for Experimental Biology and Medicine.