HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hubel, C. A. Search for Related Content PubMed PubMed Citation Articles by Hubel, C. A.

---

Original Article

Oxidative Stress in the Pathogenesis of Preeclampsia

Magee-Womens Research Institute and the Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

The etiology and pathogenesis of the pregnancy syndrome preeclampsia remain poorly understood. There is substantial evidence to suggest that the diverse manifestations of preeclampsia, including altered vascular reactivity, vasospasm, and discrete pathology in many organ systems, are derived from pathologic changes within the maternal vascular endothelium. With the theme of endothelial cell dysfunction emphasized, this review focuses on the role of oxidative stress (an imbalance favoring oxidant over antioxidant forces) in the pathogenesis of preeclampsia. Data are summarized regarding 1) the role of the placenta in preeclampsia; 2) evidence and mechanisms of oxidative stress in the preeclampsia placenta; 3) markers of oxidative stress in the maternal circulation; and 4) the potential role of maternal dyslipidemia in generation of oxidative stress. A recurrent theme is that free radical reactions, promoted by "cross-talk" between the diseased placenta and maternal dyslipidemia, promote a vicious cycle of events that make cause and effect difficult to distinguish but likely contribute to the progression of preeclampsia.

This article has been cited by other articles:

				H. Satoh, E. Kiyota, Y. Terasaki, T. Sawamura, K. Takagi, H. Mizuta, and M. Takeya Expression and Localization of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 (LOX-1) in Murine and Human Placentas J. Histochem. Cytochem., August 1, 2008; 56(8): 773 - 784. [Abstract] [Full Text] [PDF]

				L. C. Kenny, D. Broadhurst, M. Brown, W. B. Dunn, C. W. G. Redman, D. B. Kell, and P. N. Baker Detection and Identification of Novel Metabolomic Biomarkers in Preeclampsia Reproductive Sciences, July 1, 2008; 15(6): 591 - 597. [Abstract] [PDF]

				E. Mata-Greenwood and D.-B. Chen Racial Differences in Nitric Oxide--Dependent Vasorelaxation Reproductive Sciences, January 1, 2008; 15(1): 9 - 25. [Abstract] [PDF]

				A. Beausejour, V. Houde, K. Bibeau, R. Gaudet, J. St-Louis, and M. Brochu Renal and cardiac oxidative/nitrosative stress in salt-loaded pregnant rat Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1657 - R1665. [Abstract] [Full Text] [PDF]

				T. Cindrova-Davies, H.-W. Yung, J. Johns, O. Spasic-Boskovic, S. Korolchuk, E. Jauniaux, G. J. Burton, and D. S. Charnock-Jones Oxidative Stress, Gene Expression, and Protein Changes Induced in the Human Placenta during Labor Am. J. Pathol., October 1, 2007; 171(4): 1168 - 1179. [Abstract] [Full Text] [PDF]

				Y. Xia, S. M. Ramin, and R. E. Kellems Potential Roles of Angiotensin Receptor-Activating Autoantibody in the Pathophysiology of Preeclampsia Hypertension, August 1, 2007; 50(2): 269 - 275. [Full Text] [PDF]

				A. Tesse, F. Meziani, E. David, N. Carusio, H. Kremer, F. Schneider, and R. Andriantsitohaina Microparticles from preeclamptic women induce vascular hyporeactivity in vessels from pregnant mice through an overproduction of NO Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H520 - H525. [Abstract] [Full Text] [PDF]

				S. Mandang, U. Manuelpillai, and E. M Wallace Oxidative stress increases placental and endothelial cell activin A secretion J. Endocrinol., March 1, 2007; 192(3): 485 - 493. [Abstract] [Full Text] [PDF]

				S. W. Walsh What Causes Endothelial Cell Activation in Preeclamptic Women? Am. J. Pathol., October 1, 2006; 169(4): 1104 - 1106. [Full Text] [PDF]

				F. Meziani, A. Tesse, E. David, M. C. Martinez, R. Wangesteen, F. Schneider, and R. Andriantsitohaina Shed Membrane Particles from Preeclamptic Women Generate Vascular Wall Inflammation and Blunt Vascular Contractility Am. J. Pathol., October 1, 2006; 169(4): 1473 - 1483. [Abstract] [Full Text] [PDF]

				R. J.J. Ramirez, C. A. Hubel, J. Novak, J. R. DiCianno, V. E. Kagan, and R. E. Gandley Moderate Ascorbate Deficiency Increases Myogenic Tone of Arteries From Pregnant but Not Virgin Ascorbate-Dependent Rats Hypertension, March 1, 2006; 47(3): 454 - 460. [Abstract] [Full Text] [PDF]

				M. Gago-Dominguez, J. E. Castelao, M. C. Pike, A. Sevanian, and R. W. Haile Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2829 - 2839. [Abstract] [Full Text] [PDF]

				D.-b. Chen, S.-m. Li, X.-X. Qian, C. Moon, and J. Zheng Tyrosine Phosphorylation of Caveolin 1 by Oxidative Stress Is Reversible and Dependent on the c-src Tyrosine Kinase but Not Mitogen-Activated Protein Kinase Pathways in Placental Artery Endothelial Cells Biol Reprod, October 1, 2005; 73(4): 761 - 772. [Abstract] [Full Text] [PDF]

				A. T. Merchant, G. Msamanga, E. Villamor, E. Saathoff, M. O'Brien, E. Hertzmark, D. J. Hunter, and W. W. Fawzi Multivitamin Supplementation of HIV-Positive Women during Pregnancy Reduces Hypertension J. Nutr., July 1, 2005; 135(7): 1776 - 1781. [Abstract] [Full Text] [PDF]

				T. O Scholl, M. Leskiw, X. Chen, M. Sims, and T P. Stein Oxidative stress, diet, and the etiology of preeclampsia Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1390 - 1396. [Abstract] [Full Text] [PDF]

				P. Nash, M. Olovsson, and U. J. Eriksson Placental Dysfunction in Suramin-Treated Rats: Impact of Maternal Diabetes and Effects of Antioxidative Treatment Reproductive Sciences, April 1, 2005; 12(3): 174 - 184. [Abstract] [PDF]

				D. M. Shah Role of the renin-angiotensin system in the pathogenesis of preeclampsia Am J Physiol Renal Physiol, April 1, 2005; 288(4): F614 - F625. [Abstract] [Full Text] [PDF]

				L. L. Waite, R. E. Louie, and R. N. Taylor Circulating Activators of Peroxisome Proliferator-Activated Receptors Are Reduced in Preeclamptic Pregnancy J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 620 - 626. [Abstract] [Full Text] [PDF]

				S. Ahmad and A. Ahmed Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in Preeclampsia Circ. Res., October 29, 2004; 95(9): 884 - 891. [Abstract] [Full Text] [PDF]

				L. Pavan, A. Hermouet, V. Tsatsaris, P. Therond, T. Sawamura, D. Evain-Brion, and T. Fournier Lipids from Oxidized Low-Density Lipoprotein Modulate Human Trophoblast Invasion: Involvement of Nuclear Liver X Receptors Endocrinology, October 1, 2004; 145(10): 4583 - 4591. [Abstract] [Full Text] [PDF]

				M. T. M. Raijmakers, R. Dechend, and L. Poston Oxidative Stress and Preeclampsia: Rationale for Antioxidant Clinical Trials Hypertension, October 1, 2004; 44(4): 374 - 380. [Abstract] [Full Text] [PDF]

				G. J. Burton and E. Jauniaux Placental Oxidative Stress: From Miscarriage to Preeclampsia Reproductive Sciences, September 1, 2004; 11(6): 342 - 352. [Abstract] [PDF]

				S. Veerareddy, C.-L. M. Cooke, P. N. Baker, and S. T. Davidge Gender differences in myogenic tone in superoxide dismutase knockout mouse: animal model of oxidative stress Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H40 - H45. [Abstract] [Full Text] [PDF]

				C. E. Leik and S. W. Walsh Neutrophils Infiltrate Resistance-Sized Vessels of Subcutaneous Fat in Women With Preeclampsia Hypertension, July 1, 2004; 44(1): 72 - 77. [Abstract] [Full Text] [PDF]

				I. G. I. Thiele, K. E. Niezen-Koning, A. H. van Gennip, and J. G. Aarnoudse Increased Plasma Carnitine Concentrations in Preeclampsia Obstet. Gynecol., May 1, 2004; 103(5): 876 - 880. [Abstract] [Full Text] [PDF]

				T.-H. Hung, D. S. Charnock-Jones, J. N. Skepper, and G. J. Burton Secretion of Tumor Necrosis Factor-{alpha} from Human Placental Tissues Induced by Hypoxia-Reoxygenation Causes Endothelial Cell Activation in Vitro: A Potential Mediator of the Inflammatory Response in Preeclampsia Am. J. Pathol., March 1, 2004; 164(3): 1049 - 1061. [Abstract] [Full Text] [PDF]

				L. Duley Pre-eclampsia and the hypertensive disorders of pregnancy Br. Med. Bull., December 1, 2003; 67(1): 161 - 176. [Abstract] [Full Text] [PDF]

				J. M. Burlingame, N. Esfandiari, R. K. Sharma, E. Mascha, and T. Falcone Total Antioxidant Capacity and Reactive Oxygen Species in Amniotic Fluid Obstet. Gynecol., April 1, 2003; 101(4): 756 - 761. [Abstract] [Full Text] [PDF]

				R. Dechend, C. Viedt, D. N. Muller, B. Ugele, R. P. Brandes, G. Wallukat, J.-K. Park, J. Janke, P. Barta, J. Theuer, et al. AT1 Receptor Agonistic Antibodies From Preeclamptic Patients Stimulate NADPH Oxidase Circulation, April 1, 2003; 107(12): 1632 - 1639. [Abstract] [Full Text] [PDF]

				M T M Raijmakers, E M Roes, R H M te Morsche, E A P Steegers, and W H M Peters Haptoglobin and its association with the HELLP syndrome J. Med. Genet., March 1, 2003; 40(3): 214 - 216. [Full Text] [PDF]

				S. Kauma, P. Takacs, C. Scordalakes, S. Walsh, K. Green, and T. Peng Increased Endothelial Monocyte Chemoattractant Protein-1 and Interleukin-8 in Preeclampsia Obstet. Gynecol., October 1, 2002; 100(4): 706 - 714. [Abstract] [Full Text] [PDF]

				T.-H. Hung, J. N. Skepper, D. S. Charnock-Jones, and G. J. Burton Hypoxia-Reoxygenation: A Potent Inducer of Apoptotic Changes in the Human Placenta and Possible Etiological Factor in Preeclampsia Circ. Res., June 28, 2002; 90(12): 1274 - 1281. [Abstract] [Full Text] [PDF]

				R. L. Schild, W. T. Schaiff, M. G. Carlson, E. J. Cronbach, D. M. Nelson, and Y. Sadovsky The Activity of PPAR{gamma} in Primary Human Trophoblasts Is Enhanced by Oxidized Lipids J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1105 - 1110. [Abstract] [Full Text] [PDF]

				M. Toth, Z. Kukor, and S. Valent Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity Mol. Hum. Reprod., March 1, 2002; 8(3): 271 - 280. [Abstract] [Full Text] [PDF]

				A. BARBER, S. C. ROBSON, L. MYATT, J. N. BULMER, and F. LYALL Heme oxygenase expression in human placenta and placental bed: reduced expression of placenta endothelial HO-2 in preeclampsia and fetal growth restriction FASEB J, May 1, 2001; 15(7): 1158 - 1168. [Abstract] [Full Text] [PDF]

				V. A. Tyurin, S.-X. Liu, Y. Y. Tyurina, N. B. Sussman, C. A. Hubel, J. M. Roberts, R. N. Taylor, and V. E. Kagan Elevated Levels of S-Nitrosoalbumin in Preeclampsia Plasma Circ. Res., June 8, 2001; 88(11): 1210 - 1215. [Abstract] [Full Text] [PDF]