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Proceedings of the Society for Experimental Biology and Medicine 223:8-13 (2000)
© 2000 Society for Experimental Biology and Medicine

Review Article

Mechanisms of Action of Conjugated Linoleic Acid: Evidence and Speculation

Michael W. Pariza*,1, Yeonhwa Park* and Mark E. Cook*,{dagger}


* Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin-Madison, Madison, Wisconsin 53706; and
{dagger} Department of Animal Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

Conjugated linoleic acid (CLA) has been shown to inhibit carcinogenesis and atherosclerosis, enhance immunologic function while protecting against the catabolic effects of immune stimulation, affect body composition change (reducing body fat gain while enhancing lean body mass gain), and stimulate the growth of young rats. We discuss possible biochemical mechanisms that underlie these physiological effects. We emphasize the importance of considering the effects, both individually and combined, of the two CLA isomers (cis-9, trans-11 CLA and trans-10, cis-12 CLA) that have been shown to exhibit biological activity and which appear to exert their effects via different biochemical mechanisms.




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