EBM Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carr, T. P.
Right arrow Articles by Schneider, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carr, T. P.
Right arrow Articles by Schneider, C. L.
Proceedings of the Society for Experimental Biology and Medicine 223:96-101 (2000)
© 2000 Society for Experimental Biology and Medicine

Original Article

Cholesteryl Ester Enrichment of Plasma Low-Density Lipoproteins in Hamsters Fed Cereal-Based Diets Containing Cholesterol

Timothy P. Carr1,, Guowen Cai, Ji-Young Lee and Craig L. Schneider


Department of Nutritional Science and Dietetics, University of Nebraska, Lincoln, Nebraska 68583

Male Syrian hamsters were fed 0.02, 0.03, or 0.05% cholesterol to test the hypothesis that moderate cholesterol intake increases the cholesteryl ester content of the plasma low-density lipoproteins (LDL). Dietary cholesterol levels of 0.02%–0.05% were chosen to reflect typical human intakes of cholesterol. Hamsters were fed ad libitum a cereal-based diet (modified NIH-07 open formula) for 15 weeks. Increasing dietary cholesterol from 0.02% to 0.05% resulted in significantly increased plasma LDL and high-density lipoprotein cholesterol concentration, increased liver cholesterol concentration, and increased total aorta cholesterol content. The cholesteryl ester content of plasma LDL was determined as the molar ratio of cholesteryl ester to apolipoprotein B and to surface lipid (i.e., phospholipid + free cholesterol). Increasing dietary cholesterol from 0.02% to 0.05% resulted in significantly increased cholesteryl ester content of LDL particles. Furthermore, cholesteryl ester content of LDL was directly associated with increased total aorta cholesterol, whereas a linear relationship between plasma LDL cholesterol concentration and aorta cholesterol was not observed. Thus, the data suggest that LDL cholesteryl ester content may be an important atherogenic feature of plasma LDL.




This article has been cited by other articles:


Home page
 J. Nutr.Home page
T. P. Carr, C. L. Weller, V. L. Schlegel, S. L. Cuppett, D. M. Guderian Jr., and K. R. Johnson
Grain Sorghum Lipid Extract Reduces Cholesterol Absorption and Plasma Non-HDL Cholesterol Concentration in Hamsters
J. Nutr., September 1, 2005; 135(9): 2236 - 2240.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J.-Y. Lee and T. P. Carr
Dietary Fatty Acids Regulate Acyl-CoA:Cholesterol Acyltransferase and Cytosolic Cholesteryl Ester Hydrolase in Hamsters
J. Nutr., December 1, 2004; 134(12): 3239 - 3244.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. E. Dorfman, D. E. Smith, D. P. Osgood, and A. H. Lichtenstein
Study of Diet-Induced Changes in Lipoprotein Metabolism in Two Strains of Golden-Syrian Hamsters
J. Nutr., December 1, 2003; 133(12): 4183 - 4188.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. L. Cowles, J.-Y. Lee, D. D. Gallaher, C. L. Stuefer-Powell, and T. P. Carr
Dietary Stearic Acid Alters Gallbladder Bile Acid Composition in Hamsters Fed Cereal-Based Diets
J. Nutr., October 1, 2002; 132(10): 3119 - 3122.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society for Experimental Biology and Medicine.