EBM Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Steele, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Steele, T. A.
Proceedings of the Society for Experimental Biology and Medicine 223:118-127 (2000)
© 2000 Society for Experimental Biology and Medicine

Review Article

Recent Developments in the Virus Therapy of Cancer

Timothy A. Steele1,


Mercer University School of Medicine, Macon, Georgia 31207

Cancer is one of the leading causes of death in the United States. Although there has been significant progress in the areas of cancer etiology, diagnostic techniques, and cancer prevention, adequate therapeutic approaches for many cancers have lagged behind. One promising line of investigation is the virus therapy of cancer. This approach entails the use of viruses, such as retroviruses, adenovirus, and vaccinia virus, to modify tumor cells so that they become more susceptible to being killed by the host immune response, chemotherapeutic agents, or programmed cell death. This review discusses recent advances in the virus therapy of cancer from both basic science and clinical perspectives. Given the potential of viruses to kill tumor cells directly or transduce desired gene products to allow a vigorous host antitumor immune response, the virus therapy of cancer holds great promise in the treatment of cancer.




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
T. A. Steele and C. C. Hauser
The Role of Interferon- {alpha} in a Successful Murine Tumor Therapy
Experimental Biology and Medicine, July 1, 2005; 230(7): 487 - 493.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Obuchi, M. Fernandez, and G. N. Barber
Development of Recombinant Vesicular Stomatitis Viruses That Exploit Defects in Host Defense To Augment Specific Oncolytic Activity
J. Virol., August 15, 2003; 77(16): 8843 - 8856.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Fernandez, M. Porosnicu, D. Markovic, and G. N. Barber
Genetically Engineered Vesicular Stomatitis Virus in Gene Therapy: Application for Treatment of Malignant Disease
J. Virol., January 15, 2002; 76(2): 895 - 904.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Balachandran, M. Porosnicu, and G. N. Barber
Oncolytic Activity of Vesicular Stomatitis Virus Is Effective against Tumors Exhibiting Aberrant p53, Ras, or Myc Function and Involves the Induction of Apoptosis
J. Virol., April 1, 2001; 75(7): 3474 - 3479.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society for Experimental Biology and Medicine.