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Review Article

Pluripotent Hemopoietic Stem Cells in Mice and Humans

First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi, Osaka 570–8506, Japan

Although it has been reported previously that pluripotent hemopoietic stem cells (P-HSCs) express c-kit, the receptor for stem cell factor (steel factor), we and other groups have recently shown that P-HSCs do not express c-kit. In this review, we provide evidence that c-kit^<low P-HSCs in mice have long-term-reconstituting activity (LTRA > 2 years) and the capacity to form colony-forming units in spleen (CFU-S) on Day 16, although c-kit^low HSCs or c-kit⁺ HSCs have LTRA less than 1.5 years and the capacity to form CFU-S on Day 14 or on Day 10, respectively. In addition, we have found that there is a major histocompatibility complex (MHC) restriction between P-HSCs and stromal cells; normal P-HSCs can proliferate and differentiate efficiently in collaboration with MHC class I-compatible (but not MHC class I-incompatible) stromal cells. In humans, we also show that c-kit^<low P-HSCs can differentiate into c-kit^low cells, then c-kit⁺ cells in vitro.

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