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Proceedings of the Society for Experimental Biology and Medicine 223:175-182 (2000)
© 2000 Society for Experimental Biology and Medicine

Original Article

Zinc Deficiency Exacerbates Loss in Blood-Brain Barrier Integrity Induced by Hyperoxia Measured by Dynamic MRI

Michael D. Noseworthy* and Tammy M. Bray{dagger},1


* Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1; and
{dagger} Department of Human Nutrition, The Ohio State University, Columbus, Ohio 43210–1295

Using dynamic Magnetic Resonance Imaging (dMRI), blood-brain barrier (BBB) permeability (kPS{rho}) and tissue interstitial leakage space (ve) were evaluated in zinc-deficient (ZnDF) male weanling Wistar rats following 3 days exposure to hyperoxia (85% O2). Temporal monitoring of T1-weighted MR image changes, following a bolus intravenous injection of gadolinium-DTPA, allowed estimation of BBB integrity. Three-day exposure of hyperoxia caused a marginal loss of BBB integrity, reflected in a slight increase in kPS{rho} and ve, observed in both the animals fed adequate zinc (ZnAL) and pair-fed controls (ZnPF). However, zinc deficiency resulted in a significant increase in both kPS{rho} and ve, indicating a severely disturbed BBB. In addition MR-visible free water was elevated in ZnDF brains following hyperoxia treatment indicating that a loss of BBB integrity may be associated with neuronal edema. The diminished BBB integrity may be free-radical mediated as the ratio of oxidized to reduced glutathione (GSSG:GSH) was significantly elevated.




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