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Original Article

Ileal Lipid Infusion Stimulates Jejunal Synthesis of Apolipoprotein A-IV Without Affecting mRNA Levels

Department of Surgery, Louisiana State University Medical Center, Shreveport, Louisiana 71130

We examined the effect of ileal infusions of lipid emulsion on mRNA levels and biosynthesis of apolipoprotein A-IV (apo A-IV) in jejunal Thiry-Vella fistulas in rats. The rats were surgically prepared with jejunal Thiry-Vella fistulas; after recovery they were deprived of food, equipped with ileal infusion cannulas, then given 8 hr ileal infusions of fatty acid/monoglyceride emulsions. Mucosal synthesis and transcript levels of apo A-IV in the Thiry-Vella loop were then measured. Lipid infusion produced a two-fold stimulation in incorporation of ³H-leucine into apo A-IV-specific protein, but had no significant effect on apo A-IV mRNA levels. These results support the hypothesis that a lipid-elicited, distal gut-derived, systemic signal stimulates the production of apo A-IV by a post-transcriptional mechanism.

This article has been cited by other articles:

				T. J. Kalogeris and R. G. Painter Adaptation of intestinal production of apolipoprotein A-IV during chronic feeding of lipid Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1155 - R1161. [Abstract] [Full Text] [PDF]