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Experimental Biology and Medicine 226:1-4 (2001)
© 2001 Society for Experimental Biology and Medicine

MINIREVIEW

Nuclear Lipid Signaling: Novel Role of Eicosanoids

R. Stewart Gilmour and Murray D. Mitchell,1

Liggins Institute and Departments of Pharmacology & Clinical Pharmacology and Molecular Medicine, University of Auckland, Faculty of Medical and Health Sciences, Auckland, New Zealand

Nuclear lipid signaling is an established, widespread mechanism that operates in multiple cellular processes including proliferative and differentiative responses to a variety of stimuli. In this literature review with key references highlighted, we put forward the hypothesis that differential flow through various intracrine mechanisms can dictate resultant cellular actions such as mitosis, differentiation, or apoptosis.

Key Words: signalling • eicosanoids • second messengers • nucleus • intracrine




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