| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,1
* Northern Advancement Center for Science and Technology, Colabo-Hokkaido, Sapporo 001-0021, Japan; and
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
We previously demonstrated that a peptic hydrolysate of guanidinated casein strongly stimulates exocrine pancreatic secretion in chronic bile-pancreatic juice-diverted rats and cholecystokinin (CCK) release from dispersed rat intestinal mucosal cells. These results reveal that the chemically modified protein hydrolysate stimulates CCK secretion and increases pancreatic secretion by a luminal trypsin-independent direct action on the small intestine. In the present study, we examined the direct effect of peptic hydrolysates of naturally occurring dietary proteins, casein, soybean protein isolate (SPI), egg white, and wheat gluten on CCK release under in vitrotrypsin-independent conditions. All protein hydrolysates significantly stimulated CCK release from dispersed rat intestinal mucosal cells. Among the hydrolysates treated, SPI hydrolysate was the most effective in stimulating CCK release. The potential of SPI hydrolysate to stimulate CCK release was increased by long-term peptic digestion. However, an SPI-like amino acid mixture did not effect CCK release. In conclusion, peptic hydrolysates of commonly ingested dietary proteins stimulate CCK release via trypsin-independent direct sensing by intestinal mucosal cells.
Key Words: cholecystokinin release • dietary protein • mucosal cells
This article has been cited by other articles:
|
|
 |
|
  S. Choi, M. Lee, A. L. Shiu, S. J. Yo, and G. W. Aponte Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G98 - G112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P. Darcel, A. P. Liou, D. Tome, and H. E. Raybould Activation of Vagal Afferents in the Rat Duodenum by Protein Digests Requires PepT1 J. Nutr., June 1, 2005; 135(6): 1491 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hara and H. Shiota Differential Increases in Syntheses of Newly Identified Trypsinogen 2 Isoforms by Dietary Protein in Rat Pancreas Experimental Biology and Medicine, September 1, 2004; 229(8): 772 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hira, A. C. Elliott, D. G. Thompson, R. M. Case, and J. T. McLaughlin Multiple Fatty Acid Sensing Mechanisms Operate in Enteroendocrine Cells: NOVEL EVIDENCE FOR DIRECT MOBILIZATION OF STORED CALCIUM BY CYTOSOLIC FATTY ACID J. Biol. Chem., June 18, 2004; 279(25): 26082 - 26089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishi, H. Hara, K. Asano, and F. Tomita The Soybean {beta}-Conglycinin {beta} 51-63 Fragment Suppresses Appetite by Stimulating Cholecystokinin Release in Rats J. Nutr., August 1, 2003; 133(8): 2537 - 2542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aziz and G. H. Anderson Exendin-4, a GLP-1 Receptor Agonist, Interacts with Proteins and Their Products of Digestion to Suppress Food Intake in Rats J. Nutr., July 1, 2003; 133(7): 2326 - 2330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishi, H. Hara, and F. Tomita Soybean {beta}-Conglycinin Peptone Suppresses Food Intake and Gastric Emptying by Increasing Plasma Cholecystokinin Levels in Rats J. Nutr., February 1, 2003; 133(2): 352 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pupovac and G. H. Anderson Dietary Peptides Induce Satiety via Cholecystokinin-A and Peripheral Opioid Receptors in Rats J. Nutr., September 1, 2002; 132(9): 2775 - 2780. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
