EBM Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Collins, S.
Right arrow Articles by Surwit, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Collins, S.
Right arrow Articles by Surwit, R.
Experimental Biology and Medicine 226:982-990 (2001)
© 2001 Society for Experimental Biology and Medicine

SYMPOSIA

Adrenoceptors, Uncoupling Proteins, and Energy Expenditure

Sheila Collins{dagger},1, Wenhong Cao*, Kiefer W. Daniel*, Tonya M. Dixon{dagger}, Alexander V. Medvedev*, Hiroki Onuma* and Richard Surwit*

* Departments of Psychiatry and Behavioral Sciences, and
{dagger} Pharmacology, Duke University Medical Center, Durham, North Carolina 27710

Interest in the biology of adipose tissue has undergone a revival in recent years with the discovery of a host of genes that contribute to the regulation of satiety and metabolic rate. The catecholamines have long been known to be key modulators of adipose tissue lipolysis and the hydrolysis of triglyceride energy stores. However, more recent efforts to understand the role of individual adrenergic receptor subtypes expressed in adipocytes and their signal transduction pathways have revealed a complexity not previously appreciated. Combined with this interest in the modulation of adipocyte metabolism is a renewed focus upon brown adipose tissue and the mechanisms of whole body thermogenesis in general. The discovery of novel homologs of the brown fat uncoupling protein (UCP) such as UCP2 and UCP3 has provoked intensive study of these mitochondrial proteins and the role that they play in fuel metabolism. The story of the novel UCPs has proven to be intriguing and still incompletely understood. Here, we review the status of adipose tissue from inert storage depot to endocrine organ, interesting signal transduction pathways triggered by ß-adrenergic receptors in adipocytes, the potential of these receptors for discriminating and coordinated metabolic regulation, and current views on the role of UCP2 and UCP3 based on physiological studies and gene knockout models.

Key Words: ß-receptors • adipose tissue • brown fat • UCP • obesity




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Breit, M. Lagace, and M. Bouvier
Hetero-oligomerization between {beta}2- and {beta}3-Adrenergic Receptors Generates a {beta}-Adrenergic Signaling Unit with Distinct Functional Properties
J. Biol. Chem., July 2, 2004; 279(27): 28756 - 28765.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y.-H. Tseng, K. M. Kriauciunas, E. Kokkotou, and C. R. Kahn
Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
Mol. Cell. Biol., March 1, 2004; 24(5): 1918 - 1929.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
Genetically Modified Animals in Endocrinology
Endocr. Rev., August 1, 2002; 23(4): 594 - 597.
[Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
B.A. Horwitz
Introduction: Physiology, Pathophysiology, and Genetics of Body Weight/Adiposity Regulation
Experimental Biology and Medicine, December 1, 2001; 226(11): 961 - 962.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the Society for Experimental Biology and Medicine.