| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita, 879-5593 Japan
Orexins, hypothalamic neuropeptides, are involved in modulation of food intake and arousal status. To further examine their physiological roles in brain function, the effect of centrally administered orexin-A on body temperature was investigated in rats. Assessed by a telemetry sensor system implanted into the abdominal cavity, infusion of orexin-A into the third cerebroventricle (i3vt) increased body temperature in a dose-responsive manner. Expression of uncoupling protein 1 (UCP1) mRNA in brown adipose tissue (BAT), as a marker for peripheral thermogenesis, failed to increase after the infusion. Expression of UCP3 mRNA in skeletal muscle was up-regulated, whereas UCP2 in white adipose tissue was unchanged after the infusion. The resulting information indicates that orexin neurons regulate body temperature in coordination with arousal status independently of peripheral thermogenesis, which is regulated by BAT UCP1.
Key Words: Orexin-A • body temperature • thermoregulation • UCP family • telemetry sensor system
This article has been cited by other articles:
|
|
 |
|
  C. M. Kotz, J. A. Teske, and C. J. Billington Neuroregulation of nonexercise activity thermogenesis and obesity resistance Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R699 - R710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Kelz, Y. Sun, J. Chen, Q. Cheng Meng, J. T. Moore, S. C. Veasey, S. Dixon, M. Thornton, H. Funato, and M. Yanagisawa An essential role for orexins in emergence from general anesthesia PNAS, January 29, 2008; 105(4): 1309 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Guijarro, S. Suzuki, C. Chen, H. Kirchner, F. A. Middleton, S. Nadtochiy, P. S. Brookes, A. Niijima, A. Inui, and M. M. Meguid Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1474 - R1489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Conti, M. Sanchez-Alavez, R. Winsky-Sommerer, M. C. Morale, J. Lucero, S. Brownell, V. Fabre, S. Huitron-Resendiz, S. Henriksen, E. P. Zorrilla, et al. Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span Science, November 3, 2006; 314(5800): 825 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mochizuki, E. B. Klerman, T. Sakurai, and T. E. Scammell Elevated body temperature during sleep in orexin knockout mice Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R533 - R540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yasuda, T. Masaki, T. Kakuma, M. Hara, T. Nawata, I. Katsuragi, and H. Yoshimatsu Dual Regulatory Effects of Orexins on Sympathetic Nerve Activity Innervating Brown Adipose Tissue in Rats Endocrinology, June 1, 2005; 146(6): 2744 - 2748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Winsky-Sommerer, A. Yamanaka, S. Diano, E. Borok, A. J. Roberts, T. Sakurai, T. S. Kilduff, T. L. Horvath, and L. de Lecea Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response J. Neurosci., December 15, 2004; 24(50): 11439 - 11448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Zeitzer, C. L. Buckmaster, D. M. Lyons, and E. Mignot Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys J. Physiol., June 15, 2004; 557(3): 1045 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ciriello and C. V. R. de Oliveira Cardiac effects of hypocretin-1 in nucleus ambiguus Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1611 - R1620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. R. de Oliveira, M. P. Rosas-Arellano, L. P. Solano-Flores, and J. Ciriello Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1369 - H1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Taylor and W. K. Samson The other side of the orexins: endocrine and metabolic actions Am J Physiol Endocrinol Metab, January 1, 2003; 284(1): E13 - E17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Kukkonen, T. Holmqvist, S. Ammoun, and K. E. O. Akerman Functions of the orexinergic/hypocretinergic system Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1567 - C1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Aronoff Comments to the Editor Concerning the Paper Entitled ``Orexin-A Regulates Body Temperature in Coordination with Arousal Status'' by Yoshimichi et al. Experimental Biology and Medicine, January 1, 2002; 227(1): 1 - 2. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
