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ORIGINAL ARTICLE

Effects of Selected Minerals on Leptin Secretion in Streptozotocin-Induced Hyperglycemic Mice

Ming-Der Chen^*,, Vivian C. Yang, Paul S. Alexander, Pi-Yao Lin and Yuh-Min Song^*,1

^* Department of Medical Laboratories, Taichung Veterans General Hospital, Taichung 40705, Taiwan; and
Departments of Biology and
Chemistry, Tunghai University, Taichung 40705, Taiwan

The effects of lithium, magnesium, vanadate, and zinc on leptinemia and leptin secretion by adipose tissue were investigated in streptozotocin- (STZ) induced hyperglycemic mice. After the administration of studied minerals in drinking water for 4 weeks, fasting serum leptin concentrations were elevated, accompanied by normoglycemia in STZ-injected mice, regardless which mineral was provided (P < 0.05). However, the in vitro administration of lithium, magnesium, and vanadate did not significantly influence the leptin secretion of adipose tissue. A low zinc treatment (0.1 mM) augmented, whereas both a pharmacological treatment of zinc (1 mM) and zinc depletion (1 mM TPEN) attenuated, leptin secretion (P < 0.05). The present study shows that STZ-induced hyperglycemic mice have hypoleptinemia and reduced leptin secretion by adipose tissue. Moreover, these defects can be improved by a moderate zinc administration.

Key Words: leptin • lithium • magnesium • vanadium • zinc