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Experimental Biology and Medicine 226:854-859 (2001)
© 2001 Society for Experimental Biology and Medicine

ORIGINAL ARTICLE

Maximum Life Spans in Mice Are Extended by Wild Strain Alleles

Simon Klebanov, Clinton M. Astle, Thomas H. Roderick, Kevin Flurkey, Jonathan R. Archer, Jichun Chen and David E. Harrison1

The Jackson Laboratory, BarHarbor, Maine 04609

The genes that control basic aging mechanisms in mammals are unknown. By using two four-way crosses, each including a strain derived from wild, undomesticated stocks, we identified two quantitative trait loci that extend murine life spans by approximately 10%. In one cross, the longest-lived 18% of carriers of the D8Mit171 marker allele from the MOLD/Rk strain, Mus m. molossinus, outlived the longest lived 18% of noncarriers by 129 days (P = 5.4 x 10-5); in a second cross, carriers of the D10Mit267 allele from the CAST/Ei strain, Mus m. castaneus, outlived noncarriers by 125 days ( P = 1.6 x 10-6). In both crosses, P < 1.0 x 10-4 is considered significant. Because these life span increases required that all essential biological systems function longer than normal, these alleles most likely retarded basic aging mechanisms in multiple biological systems simultaneously.

Key Words: anti-aging genes • maximum life span • aging • mice • DNA markers




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