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Experimental Biology and Medicine 227:957-968 (2002)
© 2002 Society for Experimental Biology and Medicine

MINIREVIEW

Role of Nociceptin/Orphanin FQ in the Physiologic and Pathologic Control of the Cerebral Circulation1

William M. Armstead2

Departments of Anesthesia and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Nociceptin/orphanin FQ is a newly described member of the opioid family. Previous minireviews in this series have described the contribution of important factors, including opioids, in the regulation of the cerebral circulation during physiologic and pathologic conditions. The present review extends these initial comments to an opioid whose vascular actions have only very recently been appreciated. In particular, this review discusses the contribution of nociceptin/orphanin FQ to impaired cerebral hemodynamics after cerebral hypoxia/ischemia and traumatic brain injury.

Key Words: opioids • ischemia • brain injury






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Copyright © 2002 by the Society for Experimental Biology and Medicine.