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ORIGINAL ARTICLE

Alloantigen System L Affects the Outcome of Rous Sarcomas¹

Zdravka Medarova^*, W. Elwood Briles and Robert L. Taylor, Jr.^*,2

^* Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, New Hampshire 03824; and
Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115

This study was designed to examine the alloantigen system L effects on Rous sarcomas in three B complex genotypes. The parental stock was 50% Modified Wisconsin Line 3 x White Leghorn Line NIU 4 and 50% inbred Line 6.15-5. Pedigree matings of two B²B⁵ L¹L² sires to five B²B⁵ L¹L² dams per sire produced experimental chicks segregating for B and L genotypes. Chicks were inoculated with 20 pock-forming units (pfu) of Rous sarcoma virus (RSV) at 6 weeks of age. Tumors were scored six times over 10 weeks postinoculation after which the tumor scores were used to assign a tumor profile index (TPI) to each chicken. Tumor growth over time and TPI were evaluated by repeated-measures analysis of variance and analysis of variance, respectively. Six trials were conducted with a total of 151 chickens. The major histocompatibility (B) complex affected the responses as the B²B² and B²B⁵ genotypes had significantly lower tumor growth over time and TPI than the B⁵B⁵ genotype. Separate analyses revealed no significant L system effect in B²B² or B²B⁵ backgrounds. However, L genotype significantly affected (P < 0.05) both tumor growth over time and TPI in B⁵B⁵ chickens. B⁵B⁵ L¹L² birds had TPI significantly lower than B⁵B⁵ L¹L¹ chickens but not B⁵B⁵ L²L². Mortality was lower in the B⁵B⁵ L¹L² birds than in B⁵B⁵ L²L² chickens. The L system, or one closely linked, affects the growth and ultimate outcome of Rous sarcomas. The response may depend upon the genetic background as well as MHC type.

Key Words: erythrocyte alloantigen • major histocompatibility (B) complex • oncogene • Rous sarcoma virus • tumor