| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pediatrics, Division of Perinatal Medicine, University of Colorado School of Medicine, Aurora, CO 80045-0508
The concentrations of glucose, fructose, sorbitol, glycerol, and myo-inositol in sheep blood and tissues have been reported previously (1–5). However, the other polyols that are at low concentrations have not been investigated in pregnant sheep due to technical difficulties. By using HPLC and gas chromatography-mass spectrometry, seven polyols (myo-inositol, glycerol, erythritol, arabitol, sorbitol, ribitol, and mannitol) and three hexoses (mannose, glucose, and fructose) were identified and quantified in four blood vessels supplying and draining the placenta (maternal artery, uterine vein, fetal artery, and umbilical vein). Uterine and umbilical blood flows were measured, and uptakes of all the polyols and hexoses in both maternal and fetal circulations were calculated. There was a significant net placental release of sorbitol to both maternal and fetal circulations. Fructose was also taken up significantly by the uterine circulation. Maternal plasma mannose concentrations were higher than fetal concentrations, and there was a net umbilical uptake of mannose, characteristics that are similar to those of glucose. Myo-inositol and erythritol had relatively high concentrations in fetal plasma (697.8 ± 53 µM and 463.8 ± 27 µM, respectively). The ratios of fetal/maternal plasma arterial concentrations were very high for most polyols. The concentrations of myo-inositol, glycerol, and sorbitol were also high in sheep placental tissue (2489 ± 125 µM/kg wet tissue, 2119 ± 193 µM/kg wet tissue, and 3910 ± 369 µM/kg wet tissue), an indication that these polyols could be made within the placenta.
Key Words: fetal polyols • fetal-maternal gradients • ovine placental polyols • myo-inositol • mannose • sorbitol • fructose
This article has been cited by other articles:
|
|
 |
|
  M. Jozwik, M. Jozwik, C. Teng, and F. C. Battaglia Concentrations of monosaccharides and their amino and alcohol derivatives in human preovulatory follicular fluid Mol. Hum. Reprod., November 1, 2007; 13(11): 791 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. C Battaglia Placental transport: a function of permeability and perfusion Am. J. Clinical Nutrition, February 1, 2007; 85(2): 591S - 597S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Burkhardt, M. P. Jimenez de Bagues, J.-P. Liautard, and S. Kohler Analysis of the Behavior of eryC Mutants of Brucella suis Attenuated in Macrophages Infect. Immun., October 1, 2005; 73(10): 6782 - 6790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Jauniaux, J. Hempstock, C. Teng, F. C. Battaglia, and G. J. Burton Polyol Concentrations in the Fluid Compartments of the Human Conceptus during the First Trimester of Pregnancy: Maintenance of Redox Potential in a Low Oxygen Environment J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1171 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Lavrentyev, D. He, and G. A. Cook Expression of genes participating in regulation of fatty acid and glucose utilization and energy metabolism in developing rat hearts Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2035 - H2042. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
