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Experimental Biology and Medicine 227:529-534 (2002)
© 2002 Society for Experimental Biology and Medicine

ORIGINAL ARTICLE

Quantitative Trait Loci Influencing Hepatic Copper in Rats

I.D. de Wolf*,1, A.C.M. Bonné*, X.M. Fielmich-Bouman*, B.A. van Oost{dagger},,§, A.C. Beynen*,¶, L.F.M. van Zutphen* and H.A. van Lith*

* Department of Laboratory Animal Science,
{dagger} Department of Clinical Sciences of Companion Animals,
{dagger} Department of Equine Sciences,
§ Department of Farm Animal Health, and
Department of Nutrition, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, P.O. Box 80.166, NL-3508 TD Utrecht, The Netherlands

Significant differences in liver copper content have been observed between rat inbred strains. To define loci controlling this trait, the offspring (n = 190) from an (LEW/OlaHsd x BC/CpbU) F2-intercross was genetically analyzed. From each F2 animal, liver copper content was determined and genomic DNA was screened with polymorphic DNA markers. We found a major quantitative trait locus (QTL) for liver copper content in females on chromosome 2 and in males on chromosome 10. Both QTLs accounted for approximately 20% of the genetic variance. In addition, suggestive linkage for liver copper content was found on rat chromosomes 1, 8, 10, 12, 14, and 19. The regions on these chromosomes contain genes that are responsible for 9.0–15.5% of the genetic variance of liver copper content.

Key Words: copper • inbred strain • liver • QTL • rat




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