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Experimental Biology and Medicine 227:579-586 (2002)
© 2002 Society for Experimental Biology and Medicine

MINIREVIEW

Mismatch Repair Genes and Microsatellite Instability as Molecular Markers for Gynecological Cancer Detection

Roman Miturski*,1, Michal Bogusiewicz*, Carmella Ciotta{dagger}, Margherita Bignami{dagger}, Marek Gogacz* and Dominique Burnouf{ddagger}

* Second Department of Gynecological Surgery, University School of Medicine, Lublin, Poland;
{dagger} Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanita, Rome, Italy; and
{ddagger} Laboratory of Molecular Epidemiology, IRCAD-UPR 9003, Centre National de la Recherche Scientifique, Strasbourg, France

Due to major developments in genetics over the past decade, molecular biology tests are serving promising tools in early diagnosis and follow-up of cancer patients. Recent epidemiological studies revealed that the risk for each individual to develop cancer is closely linked to his/her own genetic potentialities. Some populations that are defective in DNA repair processes, for example in Xeroderma pigmentosum or in the Lynch syndrome, are particularly prone to cancer due to the accumulation of mutations within the genome. Such populations would benefit from the development of tests aimed at identifying people who are particularly at risk. Here, we review some data suggesting that the inactivation of mismatch repair is often found in endometrial cancer and we discuss molecular-based strategies that would help to identify the affected individuals in families with cases of glandular malignancies.

Key Words: glandular cancer • repair genes • microsatellite instability




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S. X. Liang, S. K. Chambers, L. Cheng, S. Zhang, Y. Zhou, and W. Zheng
Endometrial Glandular Dysplasia: A Putative Precursor Lesion of Uterine Papillary Serous Carcinoma. Part II: Molecular Features
International Journal of Surgical Pathology, October 1, 2004; 12(4): 319 - 331.
[Abstract] [PDF]


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Copyright © 2002 by the Society for Experimental Biology and Medicine.