| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203
Progress has continued to be made over the past 4 years in our understanding of the glucose-6-phosphatase (G6Pase) system. The gene for a second component of the system, the putative glucose-6-P transporter (G6PT), was cloned, and mutations in this gene were found in patients diagnosed with glycogen storage disease type 1b. The functional characterization of this putative G6PT has been initiated, and the relationship between substrate transport via the G6PT and catalysis by the system’s catalytic subunit continues to be explored. A lively debate over the feasibility of various aspects of the two proposed models of the G6Pase system persists, and the functional/structural relationships of the individual components of the system remain a hot topic of interest in G6Pase research. New evidence supportive of physiologic roles for the biosynthetic functions of the G6Pase system in vivo also has emerged over the past 4 years.
Key Words: glucose-6-phosphatase • putative glucose-6-phosphate transporter • glycogen storage disease type 1 • microsomes
This article has been cited by other articles:
|
|
 |
|
  W. Jang and R. H. Gomer A Protein in Crude Cytosol Regulates Glucose-6-phosphatase Activity in Crude Microsomes to Regulate Group Size in Dictyostelium J. Biol. Chem., June 16, 2006; 281(24): 16377 - 16383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yang, N. A. Danke, D. Berger, S. Reichstetter, H. Reijonen, C. Greenbaum, C. Pihoker, E. A. James, and W. W. Kwok Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein-Reactive CD4+ T Cells in Human Subjects. J. Immunol., March 1, 2006; 176(5): 2781 - 2789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Jang and R. H. Gomer Exposure of Cells to a Cell Number-Counting Factor Decreases the Activity of Glucose-6-Phosphatase To Decrease Intracellular Glucose Levels in Dictyostelium discoideum Eukaryot. Cell, January 1, 2005; 4(1): 72 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M C Salgado, I Meton, M Egea, and I V Baanante Transcriptional regulation of glucose-6-phosphatase catalytic subunit promoter by insulin and glucose in the carnivorous fish, Sparus aurata J. Mol. Endocrinol., December 1, 2004; 33(3): 783 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, V. Chang, S. B. Joseph, C. Trujillo, S. Bassilian, M. F. Saad, W. N. P. Lee, and I. J. Kurland Peroxisomal Proliferator-Activated Receptor {alpha} Deficiency Diminishes Insulin-Responsiveness of Gluconeogenic/Glycolytic/Pentose Gene Expression and Substrate Cycle Flux Endocrinology, March 1, 2004; 145(3): 1087 - 1095. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
