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MINIREVIEW

Developing a Laboratory Animal Model for Perinatal Endocrine Disruption: The Hamster Chronicles

William J. Hendry, III^*,,1, Daniel M. Sheehan, Shafiq A. Khan and Jeffrey V. May^*,

^* Department of Biological Sciences, Wichita State University, Wichita, Kansas 67260-0026;
The Women's Research Institute and Department of Obstetrics and Gynecology, University of Kansas School of Medicine-Wichita, Wichita, Kansas 67208;
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; and
Department of Cell Biology and Biochemistry and Southwest Cancer Center at the University Medical Center, Texas Tech University Health Sciences Center, Lubbock, Texas 79430

At the biomedical, regulatory, and public level, considerable concern surrounds the concept that inappropriate exposure to endocrine-disrupting chemicals, especially during the prenatal and/or neonatal period, may disrupt normal reproductive tract development and adult function. The intent of this review was to 1. Describe some unique advantages of the hamster for perinatal endocrine disruptor (ED) studies, 2. Summarize the morphological and molecular consequences of exposure to the established perinatal ED, diethylstilbestrol, in the female and male hamster, 3. Present some new, histomorphological insight into the process of neonatal diethylstilbestrol-induced disruption in the hamster uterus, and 4. Introduce recent efforts and future plans to evaluate the potency and mechanism of action of other putative EDs in the hamster experimental system. Taken together, the findings indicate that the hamster represents a unique and sensitive in vivo system to probe the phenomenon of endocrine disruption. The spectrum of candidate endpoints includes developmental toxicity, neoplasia, and more subtle endpoints of reproductive dysfunction.

Key Words: endocrine disruption • diethylstilbestrol • estrogen • cheek pouch • transplantation

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