HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Curtis, S. J. Articles by Prince, G. A. Search for Related Content PubMed PubMed Citation Articles by Curtis, S. J. Articles by Prince, G. A.

---

ORIGINAL ARTICLE

Age-Dependent Replication of Respiratory Syncytial Virus in the Cotton Rat

Spencer J. Curtis^*, Martin G. Ottolini, David D. Porter and Gregory A. Prince^1,*

^* Virion Systems, Inc., Rockville, Maryland;
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland;
Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Los Angeles, California

Despite the documented disease burden of respiratory syncytial virus (RSV) in the elderly, little is known about the underlying risk factors or pathogenesis of RSV in a geriatric population. This report describes an age-dependent change of RSV clearance in the lung and nose of the cotton rat. Six days postinfection with RSV, lung and nose viral titers were significantly higher in all older age groups as compared with 4- to 6-week old cotton rats (P < 0.05). When comparing the 4- to 6-week old animals to the 15- to 16-month old animals 6 days postinfection, there was over an 800- and 100-fold increase in lung and nose viral titers, respectively. The cotton rat may prove to be a useful model in eliciting mechanisms of severe RSV disease in the elderly.

Key Words: respiratory syncytial virus • elderly • cotton rat

This article has been cited by other articles:

				B. Liu and Y. Kimura Local immune response to respiratory syncytial virus infection is diminished in senescence-accelerated mice J. Gen. Virol., September 1, 2007; 88(9): 2552 - 2558. [Abstract] [Full Text] [PDF]

				M.-E. Hamelin, K. Yim, K. H. Kuhn, R. P. Cragin, M. Boukhvalova, J. C. G. Blanco, G. A. Prince, and G. Boivin Pathogenesis of Human Metapneumovirus Lung Infection in BALB/c Mice and Cotton Rats J. Virol., July 15, 2005; 79(14): 8894 - 8903. [Abstract] [Full Text] [PDF]