| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Institute for Medical Chemistry and Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria;
Institute for Pharmacology and Toxicology, University of Graz, A-8010 Graz, Austria;
Institute for Molecular Cell Biology, University of Jena, D-07740 Jena, Germany
In previous minireviews in this journal, we discussed work on induction of tetrahydrobiopterin biosynthesis by cytokines and its significance for nitric oxide (NO) production of intact cells as well as functions of H4-biopterin identified at this time for NO synthases (Proc Soc Exp Biol Med 203: 1–12, 1993; Proc Soc Exp Biol Med 219: 171–182, 1998). Meanwhile, the recognition of the importance of tetrahydrobiopterin for NO formation has led to new insights into complex biological processes and revealed possible novel pharmacological strategies to intervene in certain pathological conditions. Recent work could also establish that tetrahydrobiopterin, in addition to its allosteric effects, is redox-active in the NO synthase reaction. In this review, we summarize the current view of how tetrahydrobiopterin functions in the generation of NO and focus on pharmacological aspects of tetrahydrobiopterin availability with emphasis on endothelial function.
Key Words: tetrahydrobiopterin • nitric oxide synthase • endothelial dysfunction • reaction mechanism
This article has been cited by other articles:
|
|
 |
|
  H. Gao, G. Wu, T. E. Spencer, G. A. Johnson, and F. W. Bazer Select Nutrients in the Ovine Uterine Lumen. V. Nitric Oxide Synthase, GTP Cyclohydrolase, and Ornithine Decarboxylase in Ovine Uteri and Peri-Implantation Conceptuses Biol Reprod, July 1, 2009; 81(1): 67 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Siekmeier, T. Grammer, and W. Marz Roles of Oxidants, Nitric Oxide, and Asymmetric Dimethylarginine in Endothelial Function Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2008; 13(4): 279 - 297. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Inoue, Y. Suzuki, T. Yoshimaru, and C. Ra Nitric oxide protects mast cells from activation-induced cell death: the role of the phosphatidylinositol-3 kinase-Akt-endothelial nitric oxide synthase pathway J. Leukoc. Biol., May 1, 2008; 83(5): 1218 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Palm, M. Friederich, P.-O. Carlsson, P. Hansell, T. Teerlink, and P. Liss Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: implications for renomedullary oxygen availability Am J Physiol Renal Physiol, January 1, 2008; 294(1): F30 - F37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. van Deel, D. Merkus, R. van Haperen, M. C. de Waard, R. de Crom, and D. J. Duncker Vasomotor control in mice overexpressing human endothelial nitric oxide synthase Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1144 - H1153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fukai Endothelial GTPCH in eNOS Uncoupling and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., July 1, 2007; 27(7): 1493 - 1495. [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Werner, A. Hermetter, H. Prast, G. Golderer, and G. Werner-Felmayer Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay J. Lipid Res., June 1, 2007; 48(6): 1422 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.M. Saed, M. Zhao, M.P. Diamond, and H.M Abu-Soud Regulation of inducible nitric oxide synthase in post-operative adhesions Hum. Reprod., June 1, 2006; 21(6): 1605 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Forstermann and T. Munzel Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace Circulation, April 4, 2006; 113(13): 1708 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Rabelink and T. F. Luscher Endothelial Nitric Oxide Synthase: Host Defense Enzyme of the Endothelium? Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 267 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Lam, T. E. Peterson, D. M. Richardson, A. J. Croatt, L. V. d'Uscio, K. A. Nath, and Z. S. Katusic Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H786 - H793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Thoeni, P. Stoitzner, G. Brandacher, N. Romani, C. Heufler, G. Werner-Felmayer, and E. R. Werner Tetrahydro-4-Aminobiopterin Attenuates Dendritic Cell-Induced T Cell Priming Independently from Inducible Nitric Oxide Synthase J. Immunol., June 15, 2005; 174(12): 7584 - 7591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Griffith, A. T. Chaytor, L. M. Bakker, and D. H. Edwards 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation PNAS, May 10, 2005; 102(19): 7008 - 7013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Peterson and Z. S. Katusic Transcribing the Cross-Talk of Cytokine-Induced Tetrahydrobiopterin Synthesis in Endothelial Cells Circ. Res., February 4, 2005; 96(2): 141 - 143. [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Stuehr Enzymes of the L-Arginine to Nitric Oxide Pathway J. Nutr., October 1, 2004; 134(10): 2748S - 2751S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Li, D. J. Stuehr, S.-R. Yeh, and D. L. Rousseau Heme Distortion Modulated by Ligand-Protein Interactions in Inducible Nitric-oxide Synthase J. Biol. Chem., June 18, 2004; 279(25): 26489 - 26499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. S. Katusic and L. V. d'Uscio Tetrahydrobiopterin: Mediator of Endothelial Protection Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 397 - 398. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
