EBM Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Qi, X.
Right arrow Articles by Greeley, G. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Qi, X.
Right arrow Articles by Greeley, G. H., Jr.
Experimental Biology and Medicine 228:1028-1032 (2003)
© 2003 Society for Experimental Biology and Medicine

ORIGINAL RESEARCH ARTICLE

Evidence That Growth Hormone Exerts a Feedback Effect on Stomach Ghrelin Production and Secretion

Xiang Qi*, Jason Reed*, Ella W. Englander*, Varadaraj Chandrashekar{dagger}, Andrzej Bartke{dagger} and George H. Greeley, Jr.*,1

Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, and
* Department of Physiology, Southern Illinois University, Carbondale, Illinois 62901

Ghrelin is a recently discovered stomach hormone that stimulates pituitary growth hormone (GH) secretion potently. The purpose of these experiments was to test the hypothesis that a stomach-ghrelin-pituitary-GH axis exists in which either an elevation or reduction in systemic GH levels will exert a negative or positive feedback action, respectively, on stomach ghrelin homeostasis. In rats, GH administration decreased stomach ghrelin mRNA levels and plasma ghrelin levels significantly. In GH-releasing hormone (GHRH) transgenic mice, GHRH overexpression decreased stomach ghrelin peptide levels when compared with control mice. In aged rats (25 months) stomach ghrelin mRNA and peptide levels and plasma ghrelin levels were decreased when compared with young rats (5 months). Because GH secretion is reduced in aged rats, the elevated stomach ghrelin production and secretion may reflect a decreased GH feedback on stomach ghrelin, homeostasis, and secretion. Together, these findings suggest that endogenous pituitary GH exerts a feedback action on stomach ghrelin homeostasis and support the hypothesis that a stomach-ghrelin-pituitary GH axis exists.

Key Words: rat • mouse • pituitary




This article has been cited by other articles:


Home page
 Acta Biochim Biophys SinHome page
X. Yin, Y. Li, G. Xu, W. An, and W. Zhang
Ghrelin fluctuation, what determines its production?
Acta Biochim Biophys Sin, March 1, 2009; 41(3): 188 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Wang, N. R. Basa, A. Shaikh, A. Luckey, D. Heber, D. H. St-Pierre, and Y. Tache
LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications.
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G611 - G620.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. M. Arafat, F. H. Perschel, B. Otto, M. O. Weickert, H. Rochlitz, C. Schofl, J. Spranger, M. Mohlig, and A. F. H. Pfeiffer
Glucagon Suppression of Ghrelin Secretion Is Exerted at Hypothalamus-Pituitary Level
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3528 - 3533.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
L. C Gormsen, J. Gjedsted, S. Gjedde, E. T. Vestergaard, J. S Christiansen, J. O. Jorgensen, S. Nielsen, and N. Moller
Free fatty acids decrease circulating ghrelin concentrations in humans.
Eur. J. Endocrinol., May 1, 2006; 154(5): 667 - 673.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
N. A. Tritos and E. G. Kokkotou
The Physiology and Potential Clinical Applications of Ghrelin, a Novel Peptide Hormone
Mayo Clin. Proc., May 1, 2006; 81(5): 653 - 660.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Koutkia, S. Schurgin, J. Berry, J. Breu, B. S. H. Lee, A. Klibanski, and S. Grinspoon
Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women
Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E814 - E822.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Kojima and K. Kangawa
Ghrelin: Structure and Function
Physiol Rev, April 1, 2005; 85(2): 495 - 522.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Ghizzoni, G. Mastorakos, A. Vottero, M. Ziveri, I. Ilias, and S. Bernasconi
Spontaneous Growth Hormone (GH) Secretion Is Not Directly Affected by Ghrelin in Either Short Normal Prepubertal Children or Children with GH Neurosecretory Dysfunction
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5488 - 5495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Koutkia, B. Canavan, J. Breu, M. L. Johnson, and S. K. Grinspoon
Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E506 - E512.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Grinspoon, K. K. Miller, D. B. Herzog, K. A. Grieco, and A. Klibanski
Effects of Estrogen and Recombinant Human Insulin-Like Growth Factor-I on Ghrelin Secretion in Severe Undernutrition
J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3988 - 3993.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Society for Experimental Biology and Medicine.