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ORIGINAL RESEARCH ARTICLE

Leptin Acts Peripherally to Limit Meal-Induced Increases in Plasma Insulin Concentrations in Mice: A Brief Communication

Anahita M. Mistry^*,1, Andrew G. Swick and Dale R. Romsos

^* Department of Nutrition, Food and Exercise Science, Florida State University, Tallahassee, Florida 32306; Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, Connecticut 06340; and Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824

To whom requests for reprints should be addressed at ¹ Department of Nutrition, Food, and Exercise Science, Florida State University, Tallahassee, FL 32306-1493. E-mail: amistry{at}garnet.acns.fsu.edu

Leptin inhibits food intake and lowers plasma insulin concentrations. This study was designed to determine whether leptin acts independent of food-intake regulation to affect meal-induced increases in plasma insulin concentrations. Leptin-deficient, Lep^ob/Lep^ob mice were administered 1 µg leptin intracerebroventricularly (ICV) or intraperitoneally. Food intake and plasma insulin concentrations of mice administered leptin ICV before a meal were lower, as expected, than were intakes and plasma insulin concentrations of mice administered vehicle ICV. However when food intake was controlled, meal-induced increases in plasma insulin were unaffected by ICV administration of leptin. Intraperitoneal administration of 1 µg leptin before a meal lowered meal-induced increases in plasma insulin concentrations without influencing the size of the meal. We conclude that plasma leptin concentrations can affect meal-induced insulin secretion independent of the central nervous system actions of leptin associated with food-intake regulation.

Key Words: leptin • plasma insulin • food intake • Lep^ob • Lep^ob mice