| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, 92037
To whom requests for reprints should be addressed at 1 The Scripps Research Institute, 10550 N. Torrey Pines Road, VB-3, La Jolla, CA 92037. E-mail: loskutof{at}scrip-ps.edu
Plasminogen activator inhibitor 1 (PAI-1) is the primary physiological inhibitor of plasminogen activation in vivo, and thus it is one of the main regulators of the fibrinolytic system. In this regard, individuals with elevated PAI-1 seem to have an increased risk for thrombotic disease, whereas those lacking the inhibitor develop a lifelong bleeding diathesis. Unexpectedly, recent observations demonstrate that cancer patients with high PAI-1 levels have a poor prognosis for survival. This correlation with metastatic disease may be related to the observation that high PAI-1 levels decrease the adhesive strength of cells for their substratum, and that this de-adhesive activity of PAI-1 is not related to its role as a protease inhibitor. Initial insights into potential mechanisms by which PAI-1 regulates the attachment, detachment, and migration of cells are addressed in this review.
Key Words: plasminogen activator inhibitor 1 • vitronectin • extracellular matrix • cell attachment • cell detachment
This article has been cited by other articles:
|
|
 |
|
  A. C. Keates, S. Tummala, R. M. Peek Jr., E. Csizmadia, B. Kunzli, K. Becker, P. Correa, J. Romero-Gallo, M. B. Piazuelo, S. Sheth, et al. Helicobacter pylori Infection Stimulates Plasminogen Activator Inhibitor 1 Production by Gastric Epithelial Cells Infect. Immun., September 1, 2008; 76(9): 3992 - 3999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bryan, B. S. Paugh, D. Kapitonov, K. M. Wilczynska, S. M. Alvarez, S. K. Singh, S. Milstien, S. Spiegel, and T. Kordula Sphingosine-1-Phosphate and Interleukin-1 Independently Regulate Plasminogen Activator Inhibitor-1 and Urokinase-Type Plasminogen Activator Receptor Expression in Glioblastoma Cells: Implications for Invasiveness Mol. Cancer Res., September 1, 2008; 6(9): 1469 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aviel-Ronen, B. P. Coe, S. K. Lau, G. da Cunha Santos, C.-Q. Zhu, D. Strumpf, I. Jurisica, W. L. Lam, and M.-S. Tsao Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features PNAS, July 22, 2008; 105(29): 10155 - 10160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Paugh, S. W. Paugh, L. Bryan, D. Kapitonov, K. M. Wilczynska, S. M. Gopalan, H. Rokita, S. Milstien, S. Spiegel, and T. Kordula EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKC{delta}, and sphingosine kinase 1 in glioblastoma cells FASEB J, February 1, 2008; 22(2): 455 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Sternlicht, A. M. Dunning, D. H. Moore, P. D.P. Pharoah, D. G. Ginzinger, K. Chin, J. W. Gray, F. M. Waldman, B. A.J. Ponder, and Z. Werb Prognostic Value of PAI1 in Invasive Breast Cancer: Evidence That Tumor-Specific Factors Are More Important Than Genetic Variation in Regulating PAI1 Expression. Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2107 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Maquerlot, S. Galiacy, M. Malo, C. Guignabert, D. A. Lawrence, M.-P. d'Ortho, and G. Barlovatz-Meimon Dual Role for Plasminogen Activator Inhibitor Type 1 as Soluble and as Matricellular Regulator of Epithelial Alveolar Cell Wound Healing Am. J. Pathol., November 1, 2006; 169(5): 1624 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Deng, C. D. Gocke, J. Hess, M. Heyman, M. Paltiel, and A. Gaspari Livedoid Vasculopathy Associated With Plasminogen Activator Inhibitor-1 Promoter Homozygosity (4G/4G) Treated Successfully With Tissue Plasminogen Activator. Arch Dermatol, November 1, 2006; 142(11): 1466 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, X.-O. Shu, Q. Cai, Z. Ruan, Y.-T. Gao, and W. Zheng Functional plasminogen activator inhibitor-1 gene variants and breast cancer survival. Clin. Cancer Res., October 15, 2006; 12(20): 6037 - 6042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Lash, H. A. Otun, B. A. Innes, J. N. Bulmer, R. F. Searle, and S. C. Robson Low Oxygen Concentrations Inhibit Trophoblast Cell Invasion from Early Gestation Placental Explants via Alterations in Levels of the Urokinase Plasminogen Activator System Biol Reprod, February 1, 2006; 74(2): 403 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Fleenor, A. R. Shepard, P. E. Hellberg, N. Jacobson, I.-H. Pang, and A. F. Clark TGF{beta}2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 226 - 234. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
