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Experimental Biology and Medicine 230:1-7 (2005)
© 2005 Society for Experimental Biology and Medicine

MINIREVIEW

A Perspective on the Value of Aquatic Models in Biomedical Research

Franklin H. Epstein*,1 and Jonathan A. Epstein{dagger}

Mount Desert Island Biological Laboratory, Salisbury Cove, Maine 04672; * Division of Nephrology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215; and {dagger} Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104

To whom requests for reprints should be addressed at 1 Dana 517, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston MA 02215. E-mail: fepstein{at}bidmc.harvard.edu

For at least 150 years, biological scientists have congregated at marine laboratories, located at the edge of the sea, to explore aquatic life. The purpose of this minireview is to offer a brief perspective on the relevance of this activity to our knowledge of human physiology and disease, drawing heavily on the experience of the authors and without attempting to offer a comprehensive history of the many contributions of marine models to biomedical research.

Key Words: zebrafish • kidney • heart • animal models • teleost




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