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ORIGINAL RESEARCH ARTICLE

Blood Concentrations of Th2-Type Immunoglobulins Are Selectively Increased in Weanling Mice Subjected to Acute Malnutrition

Tirang R. Neyestani^* and Bill Woodward^,1

^* Laboratory of Nutrition Research, National Institute of Nutrition Research and Food Technology, Shaheed-Beheshti University of Medical Sciences, Tehran, Iran; and Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada

To whom requests for reprints should be addressed at ¹ Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. E-mail: wwoodwar{at}uoguelph.ca

Male and female C57BL/6J mice, initially 19 days old, consumed a complete purified diet either ad libitum (age-matched control) or in restricted daily quantities (energy deficiency), or they consumed a purified isocaloric low-protein diet ad libitum (protein and energy deficit). In a 14-day experimental period, malnourished animals lost approximately 1.5% of their initial body weight daily. Zero-time controls, 19 days old, were also included in the study. Serum levels of Th2-type (IgG1 and IgE) and Th1-type (IgG2a and IgG3) immunoglobulins were quantified by enzyme-linked immunosorbent assay, and total IgG concentration was also assessed. Both malnourished groups exhibited high serum concentrations of IgG1 and IgE relative to the age-matched control group, whereas levels of the Th1-type immunoglobulins were unaffected. Total IgG concentration in the malnourished groups reflected the usual finding in humans (i.e., no effect or elevated). The results are consistent with the proposition of Th2-polarized immune competence in acute weanling deficiencies of energy, protein, or both.

Key Words: energy deficiency • protein deficiency • immunoglobulin • blood • mice

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