HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Delgado, A. V. Articles by Chambers, J. P. Search for Related Content PubMed PubMed Citation Articles by Delgado, A. V. Articles by Chambers, J. P.

---

ORIGINAL RESEARCH ARTICLE

Exogenous Administration of Substance P Enhances Wound Healing in a Novel Skin-Injury Model

Angel V. Delgado^*, Albert T. McManus and James P. Chambers^,1

^* Combat Casualty Care Branch and Research Division, U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas 78234; and Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249

To whom requests for reprints should be addressed at ¹ Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249. E-mail: jchamber{at}utsa.edu

Soft tissue injury accounts for approximately 44% of all wounds in both the military and civilian populations. Following injury to soft tissue, Substance P (SP) and other neuropeptides are released by cutaneous neurons and modulate the function of immunocompetent and inflammatory cells, as well as epithelial and endothelial cells. The interaction between these components of the nervous system and multiple target cells affecting cutaneous repair is of increasing interest. In this report, we describe the effects of SP on wound repair in a novel, laser-induced, skin-wound model. Gross and histologic examination of laser-induced injury revealed that exogenously administered SP affects wound healing via neurite outgrowth, in addition to adhesion molecule and neurokinin-1 receptor involvement in vivo. All SP effects were decreased by pretreatment with Spantide II, an SP antagonist. The elucidation of SP-mediating mechanisms is crucial to firmly establishing the involvement and interaction of the peripheral nervous system and the immune system in cutaneous repair. Findings presented here suggest that SP participates in the complex network of mediators involved in cutaneous inflammation and wound healing.

Key Words: Substance P • CO₂ laser • wound healing • neurite outgrowth

This article has been cited by other articles:

				D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev, October 1, 2006; 86(4): 1309 - 1379. [Abstract] [Full Text] [PDF]