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ORIGINAL RESEARCH ARTICLE

Involvement of Water Channels in Synaptic Vesicle Swelling

Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201

To whom requests for reprints should be addressed at ¹ Department of Physiology, Wayne State University School of Medicine, 5245 Scott Hall, 540 E. Canfield, Detroit, MI 48201. E-mail: bjena{at}med.wayne.edu

Vesicle swelling is critical for secretion; however, the underlying mechanism of synaptic vesicle (SV) swelling is unknown. A G_i3-phospholipase A2 (PLA2)–mediated involvement of the water channel aquaporin-1 (AQP1) in the regulation of secretory vesicle swelling in the exocrine pancreas has been previously reported. In the present study, the association and involvement of water channels in SV swelling was explored. Results from the study demonstrate that water channels AQP1 and AQP6, and the heterotrimeric G_o protein are associated with SVs and participate in their swelling.

Key Words: water channels AQP1 and AQP6 • synaptic vesicle swelling • photon correlation spectroscopy • atomic force microscopy

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