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MINIREVIEW

Physiologic Interactions Between Macrophages and Leydig Cells

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430

To whom requests for reprints should be addressed at ¹ Department of Cell Biology and Biochemistry, 3601 4th Street, Texas Tech University Health Sciences Center, Lubbock, TX 79430. E-mail: jim.hutson{at}ttuhsc.edu

The purpose of this minireview is to present information concerning the morphologic and functional relationship between testicular macrophages and Leydig cells. Although data concerning the negative influence of macrophage-derived products on testicular Leydig cells exist, this review is focused on the stimulatory influences thought to be involved in the physiologic interactions between these two diverse cell types.

Key Words: testicular macrophage • 25-hydroxycholesterol • 25-hydroxylase • Leydig cells

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