| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
First Department of Internal Medicine, Sapporo Medical University, School of Medicine, Sapporo 060-8543, Japan
To whom requests for reprints should be addressed at 1 First Department of Internal Medicine, Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan. E-mail: qf39puaj{at}xg8.so-net.ne.jp
Matrix metalloproteinase (MMP)-7, also known as matrilysin, is a "minimal domain MMP" that exhibits proteolytic activity against components of the extracellular matrix (ECM). Matrilysin is frequently overexpressed in human cancer tissues and is associated with cancer progression. Tumorigenesis is a multistep process involving cell growth, invasion, metastasis, and angiogenesis. Matrilysin has been shown to play important roles not only in degradation of ECM proteins, but also in the regulation of several biochemical processes such as activation, degradation, and shedding of non-ECM proteins. This minire-view provides a summary of the current literature on the roles of matrilysin in tumorigenesis with a focus on the roles of modifications of non-ECM proteins by matrilysin and other related MMPs in tumorigenesis. Proteolysis of insulin-like growth factor binding protein by matrilysin results in increased bioavailability of insulin-like growth factors and enhanced cellular proliferation. Matrilysin has also been implicated in the ectodomain shedding of several cell surface molecules. Heparin-binding epidermal growth factor precursor (proHB-EGF) is cleaved by matrilysin into mature HB-EGF, which promotes cellular proliferation. Membrane-bound Fas ligand (FasL) is cleaved into soluble FasL, which increases apoptosis of cells adjacent to tumor cells. E-cadherin is converted to soluble E-cadherin to promote invasion. Tumor necrosis factor (TNF)-alpha precursor is cleaved to release soluble TNF-alpha to increase apoptosis. We propose that these matrilysin-mediated pathways provide the necessary and logical mechanisms to promote cancer progression.
Key Words: matrix metalloproteinase matrilysin • cancer • ectodomain shedding • apoptosis • growth
This article has been cited by other articles:
|
|
 |
|
  Y. Yokoyama, F. Grunebach, S. M. Schmidt, A. Heine, M. Hantschel, S. Stevanovic, H.-G. Rammensee, and P. Brossart Matrilysin (MMP-7) Is a Novel Broadly Expressed Tumor Antigen Recognized by Antigen-Specific T Cells Clin. Cancer Res., September 1, 2008; 14(17): 5503 - 5511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yasuhara, G. R. O. Gomes, E. R. Siu, C. I. Suenaga, E. Marostica, C. S. Porto, and M. F. M. Lazari Effects of the Antiestrogen Fulvestrant (ICI 182,780) on Gene Expression of the Rat Efferent Ductules Biol Reprod, September 1, 2008; 79(3): 432 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Beeghly-Fadiel, J.-R. Long, Y.-T. Gao, C. Li, S. Qu, Q. Cai, Y. Zheng, Z.-X. Ruan, S. E. Levy, S. L. Deming, et al. Common MMP-7 Polymorphisms and Breast Cancer Susceptibility: A Multistage Study of Association and Functionality Cancer Res., August 1, 2008; 68(15): 6453 - 6459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Guillen-Ahlers, S. A. Buechler, M. A. Suckow, F. J. Castellino, and V. A. Ploplis Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice Carcinogenesis, July 1, 2008; 29(7): 1421 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Chen, W. M. Ehrhardt, R. B. Halberg, B. J. Aronow, and W. F. Dove Cellular Expression Patterns of Genes Upregulated in Murine and Human Colonic Neoplasms J. Histochem. Cytochem., May 1, 2008; 56(5): 433 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Cooper, J. Pandhare, S. P. Donald, and J. M. Phang A Novel Function for Hydroxyproline Oxidase in Apoptosis through Generation of Reactive Oxygen Species J. Biol. Chem., April 18, 2008; 283(16): 10485 - 10492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mimeault and S. K. Batra Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies Ann. Onc., October 1, 2007; 18(10): 1605 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Klucky, R. Mueller, I. Vogt, S. Teurich, B. Hartenstein, K. Breuhahn, C. Flechtenmacher, P. Angel, and J. Hess Kallikrein 6 Induces E-Cadherin Shedding and Promotes Cell Proliferation, Migration, and Invasion Cancer Res., September 1, 2007; 67(17): 8198 - 8206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Ikonomidis, J. A. Jones, J. R. Barbour, R. E. Stroud, L. L. Clark, B. S. Kaplan, A. Zeeshan, J. E. Bavaria, J. H. Gorman III, F. G. Spinale, et al. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 1028 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Cho, Y. Jun Koh, J. Han, H.-K. Sung, H. Jong Lee, T. Morisada, R. A. Schwendener, R. A. Brekken, G. Kang, Y. Oike, et al. Angiogenic Role of LYVE-1-Positive Macrophages in Adipose Tissue Circ. Res., March 2, 2007; 100(4): e47 - e57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Davis Nutritional Interactions: Credentialing of Molecular Targets for Cancer Prevention Experimental Biology and Medicine, February 1, 2007; 232(2): 176 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Remy, C. Trespeuch, S. Bachy, J.-Y. Scoazec, and P. Rousselle Matrilysin 1 Influences Colon Carcinoma Cell Migration by Cleavage of the Laminin-5 {beta}3 Chain Cancer Res., December 1, 2006; 66(23): 11228 - 11237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-q. Wang, Y. Smicun, N. Calluzzo, and D. A. Fishman Inhibition of Matrilysin Expression by Antisense or RNA Interference Decreases Lysophosphatidic Acid-Induced Epithelial Ovarian Cancer Invasion Mol. Cancer Res., November 1, 2006; 4(11): 831 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Selleck Shedding Light on the Distinct Functions of Proteoglycans Sci. Signal., April 4, 2006; 2006(329): pe17 - pe17. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
