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Experimental Biology and Medicine 231:1739-1743 (2006)
© 2006 Society for Experimental Biology and Medicine

ORIGINAL RESEARCH ARTICLE

A BRIEF COMMUNICATION

Hepatocytes Detoxify Atuna racemosa Extract

Eric J. Buenz1

Complementary and Integrative Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905

To whom requests for reprints should be addressed at 1 BioSciential, LLC, P.O. Box 634, Rochester, MN 55903. E-mail: buenz{at}biosciential.com

A number of traditional medicine plants are hepatotoxic. Thus, while the traditional uses of Atuna racemosa suggest little indication for toxicity, it is nonetheless important to examine the potential for this extract to target the liver. Using Jurkat T cells and HepG2 hepatocytes as a model, the potential hepatotoxicity of this extract was evaluated. The results of a conditioned media experiment suggest that A. racemosa extract would likely be detoxified by the liver. These results provide the necessary background to initiate an in vivo toxicology investigation.

Key Words: detoxify • hepatotoxicity • natural product • liver • plant • extract






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Copyright © 2006 by the Society for Experimental Biology and Medicine.