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ORIGINAL RESEARCH ARTICLE

Resibufogenin Corrects Hypertension in a Rat Model of Human Preeclampsia

Hop Vu^*, Monica Ianosi-Irimie^*, Svitlana Danchuk^*, Edd Rabon, Toshihiko Nogawa, Yoshiaki Kamano, G. Robert Pettit, Thomas Wiese and Jules B. Puschett^*,1

^* Department of Medicine, Section of Nephrology, and Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112; the Cancer Research Institute, Arizona State University, Tempe, Arizona 85287; and the Xavier University of Louisiana College of Pharmacy, New Orleans, Louisiana 70125

To whom requests for reprints should be addressed at ¹ 1430 Tulane Avenue, SL45, New Orleans, LA 70112. E-mail: jpusche{at}tulane.edu

The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.

Key Words: preeclampsia • hypertension • volume-expansion • pregnancy

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