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Experimental Biology and Medicine 231:1123-1127 (2006)
© 2006 Society for Experimental Biology and Medicine

CANCER

Antitumor Effect of Green Tea Polyphenol Epigallocatechin-3-Gallate in Ovarian Carcinoma Cells: Evidence for the Endothelin-1 as a Potential Target

Francesca Spinella*, Laura Rosanò*, Samantha Decandia*, Valeriana Di Castro*, Adriana Albini{dagger}, Giacomo Elia*, Pier Giorgio Natali{ddagger} and Anna Bagnato*,1

* Molecular Pathology and Ultrastructure Laboratory, Regina Elena Cancer Institute, 00158 Rome, Italy; {dagger} National Institute for Cancer Research and Center of Advanced Biotechnology, Genoa, Italy; and {ddagger} Immunology Laboratory, Regina Elena Cancer Institute, 00158 Rome, Italy.

To whom requests for reprints should be addressed at 1 Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy. E-mail: bagnato{at}ifo.it

Abstract

The green tea polyphenol, epigallocatechin-3-gallate (EGCG), has been shown to prevent cancer; however, a precise mechanism responsible for tumor growth inhibition has not yet been clearly described. The endothelin (ET) A receptor (ETAR)/ET-1 autocrine pathway is overexpressed in ovarian carcinoma and triggers tumor growth, neoangiogenesis, and invasion. These latter tumor-promoting effects are mediated through the activation of cyclooxygenase (COX)-1– and COX-2–dependent pathways by ET-1. In the present study, pretreatment of HEY and OVCA 433 ovarian carcinoma cell lines with green tea and EGCG inhibited ET-1/ETAR expression, ETAR-mediated COX-1/2 mRNA expression, and COX-2 promoter activity. These effects were associated with a significant reduction in the COX-1/2–derived prostaglandin E2 (PGE2) production. These results provide a novel insight into the mechanism by which EGCG, by affecting ETAR-dependent COX-1/2 pathways may inhibit ovarian tumors suggesting that EGCG may be useful in preventing and treating ovarian carcinoma in which activation of ETAR by ET-1 plays a critical role in tumor growth and progression.

Key Words: endothelin-1 • ETA receptor • EGCG • green tea • ovarian carcinoma




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[Abstract] [Full Text] [PDF]


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