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Experimental Biology and Medicine 231:1271-1281 (2006)
© 2006 Society for Experimental Biology and Medicine

MINIREVIEW

Retinoblastoma Tumor Suppressor: Where Cancer Meets the Cell Cycle

Erik S. Knudsen1 and Karen E. Knudsen

Department of Cell Biology and University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio 45267-0521

To whom requests for reprints should be addressed at 1 Department of Cell Biology, 3125 Eden Avenue, Cincinnati, OH 45267-0521. E-mail: erik.knudsen{at}uc.edu

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

Key Words: E2F • RB • cyclin • cell cycle control • DNA replication • mitosis




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