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Experimental Biology and Medicine 231:1283-1286 (2006)
© 2006 Society for Experimental Biology and Medicine

MINIREVIEW

Treatment of Viral and Neoplastic Diseases with Double-Stranded RNA Derivatives and Other New Agents

Julian L. Ambrus, Sr.*,1, Kailash C. Chadha{dagger}, Anwarul Islam*, Selina Akhter* and Julian L. Ambrus, Jr.*

* Department of Internal Medicine, State University of New York at Buffalo, Buffalo General Hospital/Kaleida Health System, Buffalo, New York 14203; and {dagger} Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263

To whom requests for reprints should be addressed at 1 The Department of Internal Medicine, State University of New York at Buffalo, Buffalo General Hospital/Kaleida Health System, 100 High Street, Buffalo, NY 14203. E-mail: jlambrus{at}netscape.net

Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of double-stranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyI:MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 2'-deoxyoligocytidilates and telomerase inhibitors.

Key Words: AIDS • double-stranded and single-stranded RNA • HIV infection • neoplastic diseases • thiolated polyI:polyC (pI:MPC) • 2'-deoxyoligocytidilates • telomerase inhibitors • viral diseases






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