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5TH INTERNATIONAL CONFERENCE ON METALLOTHIONEIN SYMPOSIUM PAPERS

Metals in Motor Neuron Diseases

Per M. Roos^*,, Olof Vesterberg and Monica Nordberg^*,1

^* Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden; Department of Clinical Neurophysiology, Ullevå l University Hospital, Oslo, Norway; and Faculty of Natural Sciences, Uppsala University, Sweden

To whom requests for reprints should be addressed at ¹ Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden. E-mail: monica.nordberg{at}ki.se

Abstract

Degenerative processes within the nervous system are common features in disease entities such as dementia of Alzheimer type (DAT), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disease with unknown etiology; widespread muscle wasting and respiratory failure lead to death within a few years. Denervation can be detected with electromyography and axonal deterioration monitored by motor unit number estimates. Several suggestions about the cause of ALS have emerged but no solid theory has yet precipitated. Lead or mercury exposure has been suggested. Exposure data alone cannot support this connection. Alterations in metal kinetics may underlie the deterioration of motor function observed in patients with ALS. In this review the role of metals in motor neuron disease is discussed. Both classic studies on exposure and recent understanding of metal binding proteins are considered. Aspects of peak exposure and excretion are merged toward an understanding of metal dynamics in ALS. An overview of chemical and electrophysiological investigations is given in the context of neurodegeneration.

Key Words: neurodegenerative disease • motor neuron disease • metal • electromyography • metallothionein • cerebrospinal fluid

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