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ORIGINAL RESEARCH ARTICLE

A BRIEF COMMUNICATION

Upregulation of Interferon-Induced Genes in Infants with Virus-Associated Acute Bronchiolitis

Carolina Scagnolari^*, Fabio Midulla, Simona Trombetti^*, Alessandra Pierangeli^*, Valeria Tromba, Rosanna Grossi, Paola Di Marco^*, Caterina Dianzani, Enrico Girardi and Guido Antonelli^*,1

^* Department of Experimental Medicine, Virology Section, and Pediatric Department, Sapienza University of Rome, Rome 00185, Italy; University Campus Bio-Medico, Rome 00155, Italy; and National Institute for Infectious Diseases, L. Spallanzani, Rome 00149, Italy

To whom requests for reprints should be addressed at ¹ Department of Experimental Medicine, Virology Section, Sapienza University of Rome, V.le di Porta Tiburtina 28, 00185 Rome, Italy. E-mail: guido.antonelli{at}uniroma1.it

To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus–associated respiratory disease in early life.

Key Words: bronchiolitis • interferon • RSV • rhinovirus • PKR • 2–5 OAS • P56

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