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* Department of Experimental Medicine, Virology Section, and
Pediatric Department, Sapienza University of Rome, Rome 00185, Italy;
University Campus Bio-Medico, Rome 00155, Italy; and
National Institute for Infectious Diseases, L. Spallanzani, Rome 00149, Italy
To whom requests for reprints should be addressed at 1 Department of Experimental Medicine, Virology Section, Sapienza University of Rome, V.le di Porta Tiburtina 28, 00185 Rome, Italy. E-mail: guido.antonelli{at}uniroma1.it
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus–associated respiratory disease in early life.
Key Words: bronchiolitis interferon RSV rhinovirus PKR 2–5 OAS P56
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