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Experimental Biology and Medicine 232:390-397 (2007)
© 2007 Society for Experimental Biology and Medicine

ORIGINAL RESEARCH ARTICLE

Effects of Adiponectin on the Renal Sympathetic Nerve Activity and Blood Pressure in Rats

Mamoru Tanida*,{dagger},1, Jiao Shen*,{dagger}, Yuko Horii*,{dagger}, Morihiro Matsuda{ddagger}, Shinji Kihara{ddagger}, Toru Funahashi{ddagger}, Iichiro Shimomura{ddagger}, Hajime Sawai§, Yutaka Fukuda§, Yuji Matsuzawa{ddagger} and Katsuya Nagai*,{dagger}

* Division of Protein Metabolism, Institute for Protein Research, Osaka University, Osaka, Japan 565-0871; {dagger} ANBAS Project, Y.M.P. International Corporation, Osaka, Japan 531-0072; {ddagger} Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan 565-0871; and § Department of Physiology and Biosignaling, Osaka University Graduate School of Medicine, Osaka, Japan 565-0871

To whom requests for reprints should be addressed at 1 Y.M.P.-International Corporation, Nakajima-Building Fourth Floor, 4-12-17 Toyosaki, Kita-Ku, Osaka, 531-0071, Japan. E-mail: mtanida{at}ymp-i.co.jp

Adiponectin is an adipocytokine that modulates energy homeostasis and glucose metabolism. Here, we examined the effects of acute intravenous (iv) and lateral cerebral ventricular (LCV) injections of adiponectin on the renal sympathetic nerve activity (RSNA) and blood pressure (b/p) in urethane-anesthetized rats. Both iv and LCV injections of adiponectin induced dose-dependent suppressions of RSNA and b/p. Moreover, we found that bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of iv injection of adiponectin on RSNA and b/p. These findings suggest that adiponectin decreases the RSNA and b/p in a dose-dependent manner and that the SCN is implicated in mechanism of adiponectin actions on RSNA and b/p. These findings also suggest that the hypotensive-action activity of adiponectin is realized, at least partially, via changes in activities of autonomic nerves activity.

Key Words: adipocytokine • autonomic nervous system • cardiovascular action • hypotensive action • suprachiasmatic nucleus




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