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MINIREVIEW

Purinoceptors in the Kidney

Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912

To whom requests for reprints should be addressed at ¹ Department of Physiology, Medical College of Georgia, CA Building, CA3137, 1120 15th Street, Augusta, GA 30912. E-mail: einscho{at}mail.mcg.edu

The multiple roles of extracellular ATP and its metabolite adenosine include broad areas, such as regulating vascular tone and inducing inflammation. This review will discuss purinoceptor-induced effects on renal vascular resistance, highlighting the key experiments providing a significant contribution to our current understanding of autoregulatory mechanisms. Emphasis will be placed on the purinoceptor subtypes involved in autoregulatory control by ATP and adenosine. Additionally, the role of purinoceptors in hypertension-associated impairment of autoregulatory efficiency will be discussed.

Key Words: P1 receptors • P2 receptors • adenosine • ATP • renal microvasculature • renal autoregulation

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				V. Vallon P2 receptors in the regulation of renal transport mechanisms Am J Physiol Renal Physiol, January 1, 2008; 294(1): F10 - F27. [Abstract] [Full Text] [PDF]