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MINIREVIEW

Biogenic Amine Actions on Cholangiocyte Function

Sharon DeMorrow^*,1, Heather Francis^* and Gianfranco Alpini^,,

^* Division of Research and Education, Scott & White Hospital, Temple, Texas 76508; and Research Department, Central Texas Veterans Health Care System, Department of Medicine, Systems Biology and Translational Medicine Department, College of Medicine, Texas A&M University System Health Science Center, Temple, Texas 76504

To whom requests for reprints should be addressed at ¹ The Division of Research and Education, Medical Research Building, Scott and White Hospital, 702 S.W. H.K. Dodgen Loop, Temple, TX 76504. E-mail: demorrow{at}medicine.tamhsc.edu

Biogenic amines, such as serotonin, histamine, dopamine, and the catecholamines epinephrine and norepinephrine, regulate a multitude of cellular responses. A great deal of effort has been invested into understanding the effects of these molecules and their corresponding receptor systems on cholangiocyte secretion, apoptosis, and growth. This review summarizes the results of these efforts and highlights the importance of these regulatory molecules on the physiology and pathophysiology of cholangiocytes.

Key Words: histamine • serotonin • dopamine • adrenergic receptors • cell growth • bile duct epithelia