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Experimental Biology and Medicine 232:979-992 (2007)
doi: 10.3181/0510-MR-345
© 2007 Society for Experimental Biology and Medicine

MINIREVIEW

Bone Morphogenetic Proteins and Their Receptors in the Eye

Robert J. Wordinger*,1 and Abbot F. Clark{dagger}

* Department of Cell Biology and Genetics, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107; and {dagger} Glaucoma Research, Alcon Laboratories, Ltd., Fort Worth, Texas 76134

To whom requests for reprints should be addressed at 1 Department of Cell Biology and Genetics, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107–2699. E-mail: rwording{at}hsc.unt.edu

The human genome encodes at least 42 different members of the transforming growth factor-ß superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-ß superfamily and are involved in numerous cellular functions including development, morphogenesis, cell proliferation, apoptosis, and extracellular matrix synthesis. This article first reviews BMPs and BMP receptors, BMP signaling pathways, and mechanisms controlling BMP signaling. Second, we review BMP and BMP receptor expression during embryonic ocular development/ differentiation and in adult ocular tissues. Lastly, future research directions with respect to BMP, BMP receptors, and ocular tissues are suggested.

Key Words: bone morphogenetic proteins • bone morphogenetic protein receptors • bone morphogenetic protein signaling • ocular tissues




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BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells
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[Abstract] [Full Text] [PDF]


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