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MINIREVIEW

Mechanisms of Fibrogenesis

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0602

To whom requests for reprints should be addressed at ¹ Department of Medicine, University of California, San Diego, 1318A Biomedical Sciences Building, 9500 Gilman Drive, La Jolla, CA 92093-0602. E-mail: dbrenner{at}ucsd.edu

Fibrogenesis is a mechanism of wound healing and repair. However, prolonged injury causes deregulation of normal processes and results in extensive deposition of extracellular matrix (ECM) proteins and fibrosis. The current review will discuss similarities and differences of fibrogenesis in different organs and systems and focus on the origin of collagen producing cells. Although the relative contribution will vary in different tissues and different injuries, there are three general sources of fibrogenic cells: endogenous fibroblasts or fibroblast-like cells, epithelial to mesenchymal transition, and recruitment of fibrocytes from the bone marrow.

Key Words: fibrosis • collagen type I • fibrocytes • inflammation • EMT

This article has been cited by other articles:

				T. Kisseleva and D. A. Brenner Fibrogenesis of Parenchymal Organs Proceedings of the ATS, April 15, 2008; 5(3): 338 - 342. [Abstract] [Full Text] [PDF]