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Experimental Biology and Medicine 233:123-130 (2008)
doi: 10.3181/0707-MR-201
© 2008 Society for Experimental Biology and Medicine

MINIREVIEW

Luteinizing Hormone-Releasing Hormone I (LHRH-I) and Its Metabolite in Peripheral Tissues

Kathryn Walters, Iga N. Wegorzewska, Yue-Pui Chin, Manan G. Parikh and T. J. Wu1

Department of Obstetrics and Gynecology, and the United States Military Cancer Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814

To whom requests for reprints should be addressed at 1 Department of Obstetrics and Gynecology, Room B2020, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814. E-mail: twu{at}usuhs.mil

Luteinizing hormone-releasing hormone (LHRH) was first isolated in the mammalian hypothalamus and shown to be the primary regulator of the reproductive system through its initiation of pituitary gonadotropin release. Since its discovery, this form of LHRH (LHRH-I) has been shown to be one of many structural variants with a variety of roles in both the brain and peripheral tissues. Enormous interest has been focused on LHRH-I and LHRH-II and their cognate receptors as targets for designing therapies to treat cancers of the reproductive system. LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the fifth and sixth bond of the decapeptide (Tyr5-Gly6) to form LHRH-(1–5). We have previously reported that the autoregulation of LHRH gene expression can also be mediated by its processed peptide, LHRH-(1–5). Furthermore, LHRH-(1–5) has also been shown to be involved in cell proliferation. This review will focus on the possible roles of LHRH and its processed peptide, LHRH-(1–5), in non-hypothalamic tissues.

Key Words: luteinizing hormone-releasing hormone • gonadotropin-releasing hormone • metabolism • endopeptidase • proliferation






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