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First published online March 28, 2008
Experimental Biology and Medicine 233:496-506 (2008)
doi: 10.3181/0708-MR-231
© 2008 by the Society for Experimental Biology and Medicine
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MINIREVIEW

Nuclear Receptors and Inflammatory Diseases

Kun Wang and Yu-Jui Yvonne Wan1

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160

To whom requests for reprints should be addressed at 1 Room 4059 KLSIC, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas 66160-7417. E-mail: ywan{at}kumc.edu

It is well known that the steroid hormone glucocorticoid and its nuclear receptor regulate the inflammatory process, a crucial component in the pathophysiological process related to human diseases that include atherosclerosis, obesity and type II diabetes, inflammatory bowel disease, Alzheimer’s disease, multiple sclerosis, and liver tumors. Growing evidence demonstrates that orphan and adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors, liver x receptors, the farnesoid x receptor, NR4As, retinoid x receptors, and the pregnane x receptor, regulate the inflammatory and metabolic profiles in a ligand-dependent or -independent manner in human and animal models. This review summarizes the regulatory roles of these nuclear receptors in the inflammatory process and the underlying mechanisms.

Key Words: nuclear receptor • peroxisome proliferator-activated receptors • liver x receptors • farnesoid x receptor • NR4As • retinoid x receptors • steroid xenobiotic receptor/pregnane x receptor • inflammation • liver






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