EBM Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online March 28, 2008
Experimental Biology and Medicine 233:575-579 (2008)
doi: 10.3181/0707-RM-191
© 2008 by the Society for Experimental Biology and Medicine
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
233/5/575    most recent
0707-RM-191v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Selamoglu Talas, Z.
Right arrow Articles by Orun, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Selamoglu Talas, Z.
Right arrow Articles by Orun, I.

ORIGINAL RESEARCH ARTICLE

The Investigation of the Antioxidative Properties of the Novel Synthetic Organoselenium Compounds in Some Rat Tissues

Zeliha Selamoglu Talas*,1, Ilknur Ozdemir{dagger}, Ismet Yilmaz{dagger}, Yetkin Gok{dagger} and Ibrahim Orun{ddagger}

* Department of Biology, Faculty of Arts and Science, Nigde University, Nigde, Turkey; {dagger} Department of Chemistry, Faculty of Arts and Sciences, Inonu University, Malatya, Turkey; and {ddagger} Department of Biology, Faculty of Arts and Science, Aksaray University, Aksaray, Turkey

To whom requests for reprints should be addressed at 1 Department of Biology, Faculty of Arts and Science, Nigde University, Nigde, 51200 Turkey. E-mail: ztalas{at}nigde.edu.tr

DMBA (7,12-dimethylbenz[a]anthracene) is a polycyclic aromatic hydrocarbon (PAH) known to cause tumors in rats. Selenium is an essential element with physiological non-enzymatic antioxidant properties. Because of the health problems induced by many environmental pollutants, many efforts have been undertaken in evaluating the relative antioxidant potential of selenium and synthetic organoselenium compounds. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (1-isopropyl-3-methylbenzimidazole-2-selenone [SeI] and 1,3-di-p-methoxybenzylpyrimidine-2-selenone [SeII]) in the determined doses. The protective effects of novel synthetic organoselenium compounds (SeI and SeII) against DMBA-induced changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH) and malone-dialdehyde (MDA) levels of rat heart and brain were investigated. It was determined that SeI and SeII fully or partially restored enzyme activity. It was also found that lipid peroxidation was also decreased in SeI and SeII treated groups. Consequently, it was determined that novel synthetic organoselenium compounds (SeI and SeII) provided protection of antioxidant activity, and protection against lipid peroxidation measured as MDA in SeI and SeII treated groups was provided by novel synthesized organoselenium compounds. The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rats was rationalized.

Key Words: DMBA • brain • heart • oxidative stress • rat • synthetic organoselenium compounds






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the Society for Experimental Biology and Medicine.