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First published online April 11, 2008
Experimental Biology and Medicine 233:732-740 (2008)
doi: 10.3181/0712-RM-349
© 2008 by the Society for Experimental Biology and Medicine
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ORIGINAL RESEARCH ARTICLE

Delipidated Retroviruses as Potential Autologous Therapeutic Vaccines—A Pilot Experiment

Moiz Kitabwalla*,1, Aftab A. Ansari{dagger}, Francois Villinger{dagger}, Hassibullah Akeefe*, Adam P. Conner*, Ann E. Mayne{dagger} and James E. K. Hildreth{ddagger}

* Lipid Sciences, Inc., Pleasanton, California 94566; {dagger} Emory University School of Medicine, Atlanta, Georgia 30322; and {ddagger} Meharry Medical College, Nashville, Tennessee 37208

To whom requests for reprints should be addressed at 1 Lipid Sciences, Inc., 7068 Koll Center Parkway, Suite 401, Pleasanton, CA 94566. E-mail: mkitabwalla{at}lipidsciences.com

This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1, 1 and 10 µg of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage.

Key Words: therapeutic vaccination • SIV • delipidation






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