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Experimental Biology and Medicine 232:fmviii (2007)
© 2007 Society for Experimental Biology and Medicine

FEATURED ARTICLE

Novel 3-D Cell Culture Model Shows Selective Tumor Uptake of Nanoparticles

A nanoparticle drug delivery system designed for brain tumor therapy has shown promising tumor cell selectivity in a novel cell culture model devised by University of Nottingham scientists led by Dr. Martin Garnett. The project, conducted jointly in the Schools of Pharmacy, Biomedical Sciences and Human Development, is the featured article in this September 07 issue of Experimental Biology and Medicine.

Therapy for brain cancers is particularly difficult for a number of reasons, including getting sufficient drug to the tumor and selectivity of drug action. "We are working on a number of new therapeutic approaches using nanoparticle drug delivery systems," explained Dr Garnett, Associate Professor of drug delivery at the School of Pharmacy, "however, understanding and developing these systems requires suitable models for their evaluation."

The nanoparticles used in this study were prepared from a novel biodegradable polymer poly(glycerol adipate). The polymer has been further modified to enhance incorporation of drugs and make the nanoparticles more effective.

Tumor cell aggregates have been used as cell culture models of cancer cells for many years. Similarly thin brain slices from newborn rats can be cultured for weeks and are an important tool in brain biology. In the cell co-culture model now reported, these two techniques have been brought together for the first time. Brain tumor cell aggregates were labeled with fluorescent iron microparticles and grown on normal newborn rat-brain tissue slices. The double cell labeling technique allowed investigation of tumor cell invasion into brain tissue by either fluorescence or electron microscopy from the same samples. Using these techniques the tumor aggregates were found to invade the brain slices in a similar manner to tumors in the body. Having developed the model the investigators demonstrate the tumor selective uptake of nanoparticles in the co-culture.

You can find this article on page 1100 of this issue.





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