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First published online April 11, 2008
Experimental Biology and Medicine doi: 10.3181/0712-RM-349
© 2008 by the Society for Experimental Biology and Medicine
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Regular Manuscript

Delipidated Retroviruses as Potential Autologous Therapeutic Vaccines-A Pilot Experiment

Moiz Kitabwalla 1*, Aftab A. Ansari 2, Francois Villinger 3, Hassibullah Akeefe 1, Adam P Conner 1, Ann E Mayne 3, and James E.K. Hildreth 4

1 Lipid Sciences, Inc.
2 Emory Univ Sch of Med
3 Emory University
4 Meharry Medical College

* To whom correspondence should be addressed. E-mail: mkitabwalla{at}lipidsciences.com.


  Abstract

This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1, 1 and 10 µg of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/presentation of viral antigen eliciting potent antiviral control even at such late infection stage.

Key Words: Therapeutic vaccination, SIV, delipidation






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Copyright © 2008 by the Society for Experimental Biology and Medicine.